House Committees Demand F.D.A. Records on Alzheimer’s Drug Approval

The agency approved Biogen’s Aduhelm “despite concerns raised by experts,” committee leaders said in a letter.

#aduhelm-drug, #alzheimers-disease, #biogen-inc, #food-and-drug-administration, #your-feed-science

My Stepdad Has Alzheimer’s. Can My Mom Date Someone Else?

The magazine’s Ethicist columnist on marriage vows and stolen library books.

#alzheimers-disease, #ethics-personal, #marriages

How Exercise May Help Keep Our Memory Sharp

Irisin, a hormone produced by muscles during exercise, can enter the brain and improve cognition, a mouse study suggests.

#alzheimers-disease, #brain, #dementia, #elderly, #exercise, #hormones, #memory, #muscles

Seeking Early Signals of Dementia in Driving and Credit Scores

The pathologies underlying brain decline can begin years before symptoms emerge. Can everyday behavior provide warning?

#alzheimers-disease, #dementia, #elderly, #memory, #research, #tests-medical, #your-feed-health, #your-feed-science

Expert panel says new $56K Alzheimer’s drug is unproven—and worth $8,400 max

Multistory glass office building.

Enlarge / The exterior of the headquarters of biotechnology company Biogen in Cambridge, Massachusetts. (credit: Getty | Boston Globe)

Biogen’s new Alzheimer’s drug Aduhelm continues to face opposition after its contentious approval by the Food and Drug Administration last month—which the FDA now says should be independently investigated. Some insurers say they won’t pay for the drug, some hospitals say they won’t administer it, and yet more experts say it has no proven benefit and is dramatically overpriced at $56,000 for a year’s supply.

On Thursday, a panel of medical experts convened by the nonprofit Institute for Clinical and Economic Review (ICER) voted 15 to 0 to say that there is no evidence that Aduhelm provides clinical benefit to patients. The unanimous vote echoes another one from a panel of expert advisors for the Food and Drug Administration who voted last November against FDA approval. Eleven of ten advisors voted that data collected in two identical Phase III clinical trials failed to show that the drug is effective, with the remaining advisor voting “uncertain.”

The FDA nevertheless approved the drug on June 7, sparking a firestorm of criticism. In an unprecedented move last week, the FDA updated its recommendation for who should receive the drug, significantly narrowing the pool from all Alzheimer’s patients to only those with mild disease. It’s unusual for the FDA to make such a modification so soon after an initial decision and without fresh data to back a change.

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#alzheimers-disease, #biogen, #fda, #icer, #science

F.D.A. Requests Investigation of Its Own Alzheimer’s Drug Approval

The agency’s acting head said a federal review should look into whether any interactions between agency staff and the drug developer, Biogen, broke F.D.A. rules.

#aduhelm-drug, #alzheimers-disease, #biogen-inc, #drugs-pharmaceuticals, #food-and-drug-administration, #inspectors-general, #woodcock-janet

In a Reversal, F.D.A. Calls for Limits on Who Gets Alzheimer’s Drug

The agency faced criticism for approving Aduhelm for all Alzheimer’s patients. The new label recommends that the drug be given only to patients with mild symptoms.

#aduhelm-drug, #alzheimers-disease, #biogen-inc, #clinical-trials, #drugs-pharmaceuticals, #food-and-drug-administration, #labeling-and-labels-product

Many Alzheimer’s Experts Say Use of Aduhelm Should Be Sharply Limited

Even those who supported the F.D.A.’s approval of the controversial new drug said authorizing it for anyone with Alzheimer’s disease was much too broad.

#aduhelm-drug, #alzheimers-assn, #alzheimers-disease, #biogen-inc, #clinical-trials, #drugs-pharmaceuticals, #food-and-drug-administration, #labeling-and-labels-product, #your-feed-healthcare, #your-feed-science

The Secrets of ‘Cognitive Super-Agers’

By studying centenarians, researchers hope to develop strategies to ward off Alzheimer’s disease and slow brain aging for all of us.

#age-chronological, #alzheimers-disease, #brain, #dementia, #elderly, #memory

The F.D.A.’s Approval of Biogen’s Alzheimer’s Drug Is a New Low

The F.D.A.’s approval of the Alzheimer’s drug aducanumab is inexplicable. 

#aduhelm-drug, #alzheimers-disease, #biogen-inc, #drugs-pharmaceuticals, #food-and-drug-administration

Three experts resign as FDA advisors over approval of Alzheimer’s drug

The Food and Drug Administration headquarters in White Oak, Maryland.

Enlarge / The Food and Drug Administration headquarters in White Oak, Maryland. (credit: Getty | Congressional Quarterly)

Fallout continues from the Food and Drug Administration’s contentious decision this week to approve Biogen’s Alzheimer’s drug Aduhelm (aducanumab) despite a lack of efficacy data.

Three experts who sat on an advisory committee for the FDA have now resigned over the decision.

The advisory committee reviewed the data behind Aduhelm last November and voted overwhelmingly against approval. Of the 11 advisors on the committee, 10 voted “no” on the question of whether Biogen had collected enough evidence to indicate that the drug is effective. The remaining advisor voted “uncertain.”

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#alzheimers-disease, #biogen, #drug-approval, #fda, #science

Three F.D.A. Advisers Resign Over Agency’s Approval of Alzheimer’s Drug

The drug, Aduhelm, a monthly infusion priced at $56,000 per year, was approved this week despite weak evidence that it helps patients.

#aduhelm-drug, #alzheimers-disease, #biogen-inc, #clinical-trials, #drugs-pharmaceuticals, #elderly, #your-feed-science

Alzheimer’s Drug Is Bonanza for Biogen, Most Likely at Taxpayer Expense

Despite scant evidence that it works, the drug, Aduhelm, is predicted to generate billions of dollars in revenue, much of it from Medicare.

#alzheimers-disease, #biogen-inc, #clinical-trials, #drugs-pharmaceuticals, #health-insurance-and-managed-care

Industrial Policy, Alzheimer’s, Pizza: Your Monday Evening Briefing

Here’s what you need to know at the end of the day.

#alzheimers-disease, #economic-conditions-and-trends, #illegal-immigration, #immigration-and-emigration, #income-inequality, #indigenous-people, #law-and-legislation, #pizza, #politics-and-government, #united-states-politics-and-government

Alzheimer’s Drug Poses a Dilemma for the F.D.A.

If the agency approves it, aducanumab would be the first new Alzheimer’s treatment since 2003. Patients are desperate for new options, but some scientists say there isn’t enough evidence it works.

#aducanumab-drug, #alzheimers-assn, #alzheimers-disease, #biogen-inc, #brain, #clinical-trials, #drugs-pharmaceuticals, #elderly, #food-and-drug-administration, #memory, #your-feed-healthcare, #your-feed-science

People Want an Alzheimer’s Drug. Aducanumab Isn’t the One.

An F.D.A. sign-off for aducanumab would make finding a good treatment harder.

#alzheimers-disease, #brain, #clinical-trials, #drugs-pharmaceuticals, #placebos

Family Caregivers Feel the Pandemic’s Weight

Early studies reveal the toll that lockdowns, isolation and stress have taken on those who care for older Americans.

#alzheimers-disease, #anxiety-and-stress, #coronavirus-2019-ncov, #dementia, #depression-mental, #elderly, #home-health-care, #quarantine-life-and-culture, #your-feed-health, #your-feed-science

Aspirin May Help Protect the Brain From Pollution’s Toll, Study Suggests

Even short-term exposure to polluted air may impair mental ability in the elderly. Aspirin and other NSAIDs showed some protective effects.

#air-pollution, #alzheimers-disease, #aspirin, #brain, #dementia, #elderly, #nonsteroidal-anti-inflammatory-drugs-nsaids

Earlier Diabetes Onset Could Raise Dementia Risk

The younger the age at diagnosis for Type 2 diabetes, the higher the risk for Alzheimer’s disease and other forms of dementia years later.

#alzheimers-disease, #children-and-childhood, #dementia, #diabetes, #journal-of-the-american-medical-assn, #obesity, #weight

How Spending Mistakes Can Be Early Signs of Alzheimer’s

Impulsive purchases, out-of-control spending: These behaviors can be early signs of Alzheimer’s disease or other cognitive decline.

#alzheimers-disease, #chronic-traumatic-encephalopathy, #credit-scores, #dementia, #elderly, #frontotemporal-dementia, #memory, #personal-finances, #retirement, #stocks-and-bonds

Doctors Harness the Power of Human Connections

Social medicine programs, which often encourage patients to engage with other people, can help address dementia, isolation and more.

#alzheimers-disease, #dementia, #doctors, #elderly, #loneliness, #parkinsons-disease, #therapy-and-rehabilitation

They Have Alzheimer’s. This Clinical Trial May Be a Last Hope.

In the narrow window in which patients are aware of their disease, they have sought help in clinical trials. But enrolling enough participants to make these trials count is not easy.

#alzheimers-assn, #alzheimers-disease, #brain, #clinical-trials, #eli-lilly-and-company, #memory

Sleeping Too Little in Middle-Age May Raise Dementia Risk, Study Finds

The research, tracking thousands of people from age 50 on, suggests those who sleep six hours or less a night are more likely to develop dementia in their late 70s.

#alzheimers-disease, #brain, #dementia, #great-britain, #nerves-and-nervous-system, #research, #sleep, #your-feed-healthcare

Walking and Other Aerobic Exercise May Aid the Aging Brain

Older people with mild cognitive impairment showed improvements in brain blood flow and memory after a yearlong aerobic exercise program.

#age-chronological, #alzheimers-disease, #brain, #carotid-arteries, #elderly, #exercise, #journal-of-alzheimers-disease, #memory, #university-of-texas-southwestern-medical-center

Learning to Love a Stepmother Through the Language of Flowers

I loved the strenuous labor, the smell of the upturned soil as I planted a seed, and learning from her how to shepherd a plant through its life cycle.

#alzheimers-disease, #dating-and-relationships, #flowers-and-plants, #gardens-and-gardening, #marriages

NFL’s Concussion Settlement Will Look at Racial Bias in Payouts

Mediation in the case could force a reopening of hundreds of denied dementia claims from Black players if race-based evaluation benchmarks are thrown out.

#alzheimers-disease, #black-people, #brody-anita-b, #concussions, #davenport-najeh-1979, #discrimination, #henry-kevin-1968, #national-football-league, #race-and-ethnicity, #suits-and-litigation-civil

How Pandemic Isolation Affected an Alzheimer’s Patient in a Nursing Home

The pandemic has stolen away the chance to surround the sister we are losing to dementia with our love, so that she does not have to face death alone.

#alzheimers-disease, #bipolar-disorder, #coronavirus-2019-ncov, #families-and-family-life, #nursing-homes, #vaccination-and-immunization

A Year of Unraveling

For the millions of Americans living with dementia, every day during this pandemic can bring a fresh horror.

#alzheimers-assn, #alzheimers-disease, #coronavirus-2019-ncov, #dementia, #elder-care, #elderly, #health-insurance-and-managed-care, #national-institute-on-aging, #nursing-and-nurses, #nursing-homes

Marty Schottenheimer, 77, Winning N.F.L. Coach With Four Teams, Dies

With a running attack known as Martyball, his teams won 200 regular season games and reached the playoffs 13 times but never made it to the Super Bowl.

#alzheimers-disease, #american-football-conference, #cleveland-browns, #coaches-and-managers, #deaths-obituaries, #kansas-city-chiefs, #los-angeles-chargers, #national-football-league, #playoff-games, #washington-redskins

Study Finds People With Dementia Are Twice as Likely to Get Covid

The analysis of nearly 62 million electronic medical records in the U.S. also found that Black people with dementia were at an even greater risk.

#alzheimers-assn, #alzheimers-disease, #case-western-reserve-university, #coronavirus-2019-ncov, #dementia, #elderly, #research, #your-feed-science

Modern Love: The Day His Journal Went Blank

A daughter races to collect her father’s memories before Alzheimer’s can steal them away.

#alzheimers-disease, #love-emotion, #parenting

Tony Bennett Reveals He Has Alzheimer’s Disease

“He’s not the old Tony anymore,” his wife, Susan, said. “But when he sings, he’s the old Tony.”

#alzheimers-assn, #alzheimers-disease, #bennett-tony, #elderly, #memory, #music, #pop-and-rock-music

Alzheimer’s Prediction May Be Found in Writing Tests

IBM researchers trained artificial intelligence to pick up hints of changes in language ahead of the onset of neurological diseases.

#alzheimers-disease, #artificial-intelligence, #dementia, #international-business-machines-corporation, #mental-health-and-disorders, #research, #tests-medical

Eli Lilly’s Alzheimer’s Drug Shows Promise in Small Trial

Participants with the disease still declined, but much more slowly than those receiving a placebo, investigators say.

#alzheimers-disease, #clinical-trials, #donanemab, #drugs-pharmaceuticals, #eli-lilly-and-company, #research

Nursing Home Patients Are Dying of Loneliness

As the vaccine rolls out in nursing homes, more visits should be allowed.

#alzheimers-disease, #coronavirus-2019-ncov, #elder-care, #elderly, #loneliness, #nursing-homes, #quarantine-life-and-culture

Alzheimer’s Researchers Study a Rare Brain

A woman in Colombia with a rare genetic mutation recently made the ultimate donation to science.

#aliria-rosa-piedrahita-de-villegas, #alzheimers-disease, #boston-mass, #brain, #dementia, #genetics-and-heredity, #harvard-university, #lopera-francisco, #massachusetts-general-hospital, #medellin-colombia, #research, #university-of-antioquia, #your-feed-health, #your-feed-science

Singing My Dad Back to Me

For a moment, songs let us share the same space in our minds, though it’s only as temporary as the memory occupying his.

#alzheimers-disease, #elderly, #families-and-family-life, #memory, #music, #parenting

Controversial Alzheimer’s Drug Faces Critical Test Before F.D.A. Panel

If ultimately approved, the drug, aducanumab, made by Biogen, would be the first new Alzheimer’s treatment in nearly two decades. Some evidence suggests it slows, but does not stop, cognitive decline.

#alzheimers-disease, #biogen-inc, #clinical-trials, #drugs-pharmaceuticals, #food-and-drug-administration, #your-feed-science

Nursing Homes, Racked by the Virus, Face a New Crisis: Isolation

Nursing homes set restrictions to lower risks, but Covid-19 has continued spreading in some homes, and residents are now grappling with consequences from isolation.

#alzheimers-disease, #american-health-care-assn, #coronavirus-2019-ncov, #deaths-fatalities, #depression-mental, #disease-rates, #elder-care, #elderly, #kirkland-wash, #loneliness, #nursing-homes

Living in Noisy Neighborhoods May Raise Your Dementia Risk

As community noise levels increased, so did the risk of Alzheimer’s disease and other forms of dementia.

#alzheimers-disease, #dementia, #elderly, #noise

Why Are TikTok Teens Listening to an Album About Dementia?

Creepypasta meets esoterica in an ongoing meme.

#alzheimers-disease, #everywhere-at-the-end-of-time-musical-work, #kirby-leyland-james, #tiktok-bytedance

The Pandemic’s Real Toll? 300,000 Deaths, and It’s Not Just From the Coronavirus

A C.D.C. analysis finds that overall death rates have risen, particularly among young adults and people of color.

#alzheimers-disease, #black-people, #centers-for-disease-control-and-prevention, #coronavirus-2019-ncov, #deaths-fatalities, #diabetes, #heart, #jama-journal-of-american-medical-assn, #millennial-generation, #minorities, #native-americans, #statistics, #united-states, #your-feed-science

Having Dementia Doesn’t Mean You Can’t Vote

Yes, you can help a cognitively impaired person participate in the election. But heed these two guidelines.

#absentee-voting, #alzheimers-disease, #content-type-service, #dementia, #disabilities, #elderly, #nursing-homes, #presidential-election-of-2020, #retirement-communities-and-assisted-living, #voter-registration-and-requirements, #your-feed-health, #your-feed-science

Will They See Me as a Son, a Daughter or a Stranger?

Thirteen years ago, my parents tried to wish away my gender transition. Now, Alzheimer’s threatens to erase their memory of me altogether.

#alzheimers-disease, #love-emotion, #memory, #transgender-and-transsexuals

Judge Agrees to Retire After Alzheimer’s Diagnosis

Judge ShawnDya L. Simpson, 54, agreed to step down after the Commission on Judicial Conduct determined her behavior in court was “erratic and at times intemperate.”

#alzheimers-disease, #appointments-and-executive-changes, #commission-on-judicial-conduct-nys, #simpson-shawndya-l, #tembeckjian-robert-h

Dementia on the Retreat in the U.S. and Europe

Rates of dementia have steadily fallen over the past 25 years, a new study finds. But the disease is increasingly common in some parts of the world.

#alzheimers-disease, #blood-pressure, #dementia, #disease-rates, #elderly, #harvard-university, #neurology-journal, #united-states

‘Amazing, Isn’t It?’ Long Sought Blood Test for Alzheimer’s in Reach

Scientists say such tests could be available in a few years, speeding research for treatments and providing a diagnosis for dementia patients who want to know if they have Alzheimer’s disease.

#alzheimers-assn, #alzheimers-disease, #clinical-trials, #dementia, #eli-lilly-and-company, #frontotemporal-dementia, #journal-of-the-american-medical-assn, #lund-university, #research, #tests-medical, #university-of-california-san-francisco, #your-feed-science

Trump Says He ‘Aced’ a Cognitive Test. What Does That Really Mean?

Experts say one popular test that the president might have taken is by no means definitive, or even diagnostic.

#alzheimers-disease, #biden-joseph-r-jr, #dementia, #elderly, #memory, #presidential-election-of-2020, #tests-medical, #trump-donald-j, #united-states-politics-and-government, #your-feed-elections, #your-feed-health, #your-feed-science

I Miss My Father’s Mind

Was he one of the hidden victims of the coronavirus pandemic?

#alzheimers-disease, #coronavirus-2019-ncov, #dementia, #loneliness, #therapy-and-rehabilitation

Pride Through Repetition

Coming out repeatedly to my grandmother with Alzheimer’s allowed me to fully embrace my queer identity.

#alzheimers-disease, #dating-and-relationships, #families-and-family-life, #grandparents, #homosexuality-and-bisexuality