Pope Francis, Slowed by Aging, Finds Lessons in Frailty

On a visit to Canada, the pontiff, 85, used his own vulnerability to demand dignity and respect for older people in a world increasingly populated by them.

#canada, #elderly, #francis, #longevity, #roman-catholic-church

Exercise or Diet Alone Isn’t Enough to Prevent Disease, Study Shows

Sprawling new research showed that healthy eating and regular workouts do not, in isolation, stave off later health issues. They need to be done together.

#cancer, #content-type-service, #diet-and-nutrition, #exercise, #health-foods, #heart, #longevity, #research

Who’s the Oldest of Them All?

Two towns in Sardinia battle for the distinction of having the longest-living residents. One has the imprimatur of Guinness World Records.

#elderly, #guinness-world-records, #italy, #longevity, #perdasdefogu-italy, #records-and-achievements, #sardinia-italy

Centenarian Tortoises May Set the Standard for Anti-Aging

Tortoises and turtles don’t just live for a long time — they barely age while they live.

#biology-and-biochemistry, #ectotherm, #endotherm, #longevity, #research, #science-journal, #turtles-and-tortoises, #your-feed-science

Exploring the Health Effects of Ageism

Through more than three decades of research, the Yale psychologist Becca Levy has demonstrated that age discrimination can take years off one’s life.

#age-chronological, #content-type-personal-profile, #discrimination, #elderly, #levy-becca, #longevity, #mental-health-and-disorders, #psychology-and-psychologists, #research, #yale-university, #your-feed-health, #your-feed-science

4 Ways to Fortify Your Retirement Against Market Volatility

So many factors cause volatility in the markets, making it tricky even for the experts to know what’s next. They still have ideas.

#benz-chris-1982, #content-type-service, #ibbotson-roger, #inflation-economics, #investing, #longevity, #personal-finances, #reichenstein-william, #retirement, #social-security-us, #stocks-and-bonds, #united-states-economy

Can Your Diet Help Prevent Dementia?

Here’s what the science says about whether your diet can counteract cognitive decline.

#age-chronological, #alzheimers-disease, #animal-behavior, #dementia, #diet-and-nutrition, #dietary-supplements-and-herbal-remedies, #health-foods, #longevity, #obesity, #oils-and-fats, #research, #vegetables, #weight

Is 30 Minutes of Exercise a Day Enough?

Science says you may need less exercise than you think to live a long and healthy life.

#content-type-service, #exercise, #lancet-the-journal, #longevity

Living With Gusto Despite a Rare, Fatal Disease, and Hunting for Answers

At 26, Sammy Basso is believed to be the oldest person with the disease Progeria. And now he’s researching it, hoping to find a treatment and the secrets of aging.

#italy, #longevity, #progeria, #research

Dagny Carlsson, Centenarian Blogger, Dies at 109

She began posting about her daily life in Sweden at the age of 99. She went on to acquire a worldwide fan base.

#blogs-and-blogging-internet, #carlsson-dagny-1912-2022, #deaths-obituaries, #elderly, #longevity, #sweden

Justin Verlander Thinks He Can Win 300 Games

“Can I do that? Yeah,” Verlander said, matter-of-factly, when asked about reaching 300 wins. An “aberration” among modern pitchers, it is unwise to bet against him.

#baseball, #houston-astros, #longevity, #sports-injuries, #verlander-justin

Keeping Handball Alive at Flamingo Park

In between trash talk and the discussion of various ailments, a dedicated group of seniors hopes to carry a sport to a new generation.

#florida, #handball, #longevity, #miami-beach-fla, #south-beach-miami-beach-fla

How to Transition Into Retirement

Many older Americans like to ease into being an ex-worker — but you need to think carefully about just how to get there.

#age-chronological, #content-type-service, #labor-and-jobs, #longevity, #medicare, #pensions-and-retirement-plans, #personal-finances, #retirement, #social-security-us, #social-security-administration

What the ‘Active Grandparent Hypothesis’ Tells Us About Aging Well

The need for healthy, active grandparents who can help with child-rearing may be encoded in our genes.

#diabetes, #elderly, #exercise, #grandparents, #longevity

Using Tech to Optimize Your Social Security Benefits

A variety of online tools can guide retirees looking to make the most of this benefit — which many older Americans depend on.

#age-chronological, #computers-and-the-internet, #content-type-service, #financial-planners, #longevity, #personal-finances, #retirement, #social-security-us, #taxation

Walking Just 10 Minutes a Day May Lead to a Longer Life

Ten minutes of moderate exercise daily would prevent more than 111,000 premature deaths a year, a new analysis found.

#exercise, #longevity, #medicine-and-health, #walking

Notes From the End of a Very Long Life by New York’s Oldest

With the death of Ruth Willig at 98, a Times series on a set of the oldest New Yorkers — chronicled over seven years in 21 articles — offers their lessons on living with loss.

#content-type-personal-profile, #death-and-dying, #elder-care, #elderly, #longevity, #mekas-jonas, #moses-helen-1924, #new-york-city, #willig-ruth-1923

The Secrets to Successful Aging in 2022

Advice from Well’s most popular stories of the year.

#age-chronological, #content-type-service, #digestive-tract, #elderly, #exercise, #longevity

How to Cope With Medicare’s Rising Costs

A higher Medicare premium in 2022 is just part of the puzzle of health care costs for older Americans. But there are ways to plan.

#aduhelm-drug, #content-type-service, #drugs-pharmaceuticals, #elderly, #finances, #health-insurance-and-managed-care, #inflation-economics, #longevity, #medicare, #pensions-and-retirement-plans, #social-security-us

You’re Going to Work a Long Time. Here’s How to Build in Breaks.

Living longer can mean having a longer career, whether by choice or necessity. Stopping and starting isn’t easy, but it might be worth it.

#age-chronological, #content-type-service, #labor-and-jobs, #longevity, #personal-finances, #retirement

Can an Athlete’s Blood Enhance Brainpower?

Scientists who injected idle mice with blood from athletic mice found improvements in learning and memory. The findings could have implications for Alzheimer’s research and beyond.

#alzheimers-disease, #animal-cognition, #brain, #elderly, #exercise, #longevity, #memory, #mice, #nature-journal, #proteins, #research, #stanford-university, #tests-medical, #veterans, #veterans-affairs-department, #your-feed-science

The Key to Marketing to Older People? Don’t Say ‘Old.’

To reach a rapidly expanding demographic, companies are changing their tone.

#advertising-and-marketing, #age-chronological, #elderly, #longevity

As We Live Longer, How Should Life Change? There Is a Blueprint.

“The New Map of Life” reimagines education, careers, cities and life transitions for lives that span a century (or more).

#carstensen-laura, #elderly, #government-accountability-office, #longevity, #national-academies-of-the-united-states, #stanford-university

What Is HIIT and How Does the Training Benefit Your Health?

What you need to know about high-intensity interval training, or HIIT.

#content-type-service, #exercise, #heart, #longevity, #muscles, #weight

How to Drive Safely When You’re an Older Driver

Safe driving is possible for many people in their 70s, 80s and beyond, provided they take steps to maintain their skills.

#aarp, #age-chronological, #american-automobile-assn, #automobile-insurance-and-liability, #automobile-safety-features-and-defects, #content-type-service, #deaths-fatalities, #elderly, #exercise, #eyes-and-eyesight, #insurance-institute-for-highway-safety, #loneliness, #longevity, #roads-and-traffic, #traffic-accidents-and-safety

Join Us for a Conversation on the Business of Longevity

On Oct. 12, the Harvard researcher and biotech company founder David Sinclair talks with Andrew Ross Sorkin about the quest for immortality.

#biotechnology-and-bioengineering, #internal-open-access, #longevity, #sinclair-david-andrew-1969

Why Exercise Is More Important Than Weight Loss for a Longer Life

People typically lower their risks of heart disease and premature death far more by gaining fitness than by dropping weight.

#cholesterol, #diabetes, #exercise, #heart, #iscience-journal, #longevity, #obesity, #weight

Cancer Without Chemotherapy: ‘A Totally Different World’

A growing number of cancer patients, especially those with breast and lung cancers, are being spared the dreaded treatment in favor of other options.

#breast-cancer, #chemotherapy, #drugs-pharmaceuticals, #genetics-and-heredity, #immunotherapy, #longevity, #lung-cancer, #tumors, #women-and-girls

How Many Daily Steps Should You Take to Live Longer?

Two studies suggest the sweet spot for longevity lies around 7,000 to 8,000 daily steps or about 30 to 45 minutes of exercise most days.

#deaths-fatalities, #exercise, #heart, #longevity, #wearable-computing

The Best Sport for a Longer Life? Try Tennis.

People who played tennis, badminton or soccer tended to live longer than those who cycled, swam or jogged.

#athletics-and-sports, #badminton, #heart, #leisure, #longevity, #soccer, #sporting-goods-and-equipment, #tennis

Do We Really Need to Take 10,000 Steps a Day for Our Health?

The advice that we take 10,000 steps a day is more a marketing accident than based on science. Taking far fewer may have notable benefits.

#content-type-service, #exercise, #longevity, #medicine-and-health, #walking

Women and Social Security: How to Get the Biggest Check

Women tend to live longer than men, so they need as much retirement income as possible. Whether you’re 30 or 60, here’s what you need to know.

#content-type-service, #divorce-separations-and-annulments, #elderly, #income, #longevity, #retirement, #social-security-us, #social-security-administration, #widows-and-widowers, #women-and-girls

The Best Type of Exercise? A Blood Test Holds Clues

Researchers are studying the proteins in blood to learn why some of us respond to certain forms of exercise better than others.

#exercise, #longevity, #weight

Life Expectancy Could Rise a Lot. Here’s What it Means.

What happens if we slow down aging?

#age-chronological, #ageless-the-new-science-of-getting-older-without-getting-old-book, #longevity, #olshansky-s-jay, #steele-andrew-author, #united-states

How Humans Gained an ‘Extra Life’

In Steven Johnson’s latest book, he looks at what he calls “one of the greatest achievements in the history of our species,” that life spans have more than doubled since the mid-19th century.

#books-and-literature, #extra-life-a-short-history-of-living-longer-book, #johnson-steven-berlin, #longevity, #medicine-and-health

Longevity startup Gero AI has a mobile API for quantifying health changes

Sensor data from smartphones and wearables can meaningfully predict an individual’s ‘biological age’ and resilience to stress, according to Gero AI.

The ‘longevity’ startup — which condenses its mission to the pithy goal of “hacking complex diseases and aging with Gero AI” — has developed an AI model to predict morbidity risk using ‘digital biomarkers’ that are based on identifying patterns in step-counter sensor data which tracks mobile users’ physical activity.

A simple measure of ‘steps’ isn’t nuanced enough on its own to predict individual health, is the contention. Gero’s AI has been trained on large amounts of biological data to spots patterns that can be linked to morbidity risk. It also measures how quickly a personal recovers from a biological stress — another biomarker that’s been linked to lifespan; i.e. the faster the body recovers from stress, the better the individual’s overall health prognosis.

A research paper Gero has had published in the peer-reviewed biomedical journal Aging explains how it trained deep neural networks to predict morbidity risk from mobile device sensor data — and was able to demonstrate that its biological age acceleration model was comparable to models based on blood test results.

Another paper, due to be published in the journal Nature Communications later this month, will go into detail on its device-derived measurement of biological resilience.

The Singapore-based startup, which has research roots in Russia — founded back in 2015 by a Russian scientist with a background in theoretical physics — has raised a total of $5 million in seed funding to date (in two tranches).

Backers come from both the biotech and the AI fields, per co-founder Peter Fedichev. Its investors include Belarus-based AI-focused early stage fund, Bulba Ventures (Yury Melnichek). On the pharma side, it has backing from some (unnamed) private individuals with links to Russian drug development firm, Valenta. (The pharma company itself is not an investor).

Fedichev is a theoretical physicist by training who, after his PhD and some ten years in academia, moved into biotech to work on molecular modelling and machine learning for drug discovery — where he got interested in the problem of ageing and decided to start the company.

As well as conducting its own biological research into longevity (studying mice and nematodes), it’s focused on developing an AI model for predicting the biological age and resilience to stress of humans — via sensor data captured by mobile devices.

“Health of course is much more than one number,” emphasizes Fedichev. “We should not have illusions about that. But if you are going to condense human health to one number then, for a lot of people, the biological age is the best number. It tells you — essentially — how toxic is your lifestyle… The more biological age you have relative to your chronological age years — that’s called biological acceleration — the more are your chances to get chronic disease, to get seasonal infectious diseases or also develop complications from those seasonal diseases.”

Gero has recently launched a (paid, for now) API, called GeroSense, that’s aimed at health and fitness apps so they can tap up its AI modelling to offer their users an individual assessment of biological age and resilience (aka recovery rate from stress back to that individual’s baseline).

Early partners are other longevity-focused companies, AgelessRx and Humanity Inc. But the idea is to get the model widely embedded into fitness apps where it will be able to send a steady stream of longitudinal activity data back to Gero, to further feed its AI’s predictive capabilities and support the wider research mission — where it hopes to progress anti-ageing drug discovery, working in partnerships with pharmaceutical companies.

The carrot for the fitness providers to embed the API is to offer their users a fun and potentially valuable feature: A personalized health measurement so they can track positive (or negative) biological changes — helping them quantify the value of whatever fitness service they’re using.

“Every health and wellness provider — maybe even a gym — can put into their app for example… and this thing can rank all their classes in the gym, all their systems in the gym, for their value for different kinds of users,” explains Fedichev.

“We developed these capabilities because we need to understand how ageing works in humans, not in mice. Once we developed it we’re using it in our sophisticated genetic research in order to find genes — we are testing them in the laboratory — but, this technology, the measurement of ageing from continuous signals like wearable devices, is a good trick on its own. So that’s why we announced this GeroSense project,” he goes on.

“Ageing is this gradual decline of your functional abilities which is bad but you can go to the gym and potentially improve them. But the problem is you’re losing this resilience. Which means that when you’re [biologically] stressed you cannot get back to the norm as quickly as possible. So we report this resilience. So when people start losing this resilience it means that they’re not robust anymore and the same level of stress as in their 20s would get them [knocked off] the rails.

“We believe this loss of resilience is one of the key ageing phenotypes because it tells you that you’re vulnerable for future diseases even before those diseases set in.”

“In-house everything is ageing. We are totally committed to ageing: Measurement and intervention,” adds Fedichev. “We want to building something like an operating system for longevity and wellness.”

Gero is also generating some revenue from two pilots with “top range” insurance companies — which Fedichev says it’s essentially running as a proof of business model at this stage. He also mentions an early pilot with Pepsi Co.

He sketches a link between how it hopes to work with insurance companies in the area of health outcomes with how Elon Musk is offering insurance products to owners of its sensor-laden Teslas, based on what it knows about how they drive — because both are putting sensor data in the driving seat, if you’ll pardon the pun. (“Essentially we are trying to do to humans what Elon Musk is trying to do to cars,” is how he puts it.)

But the nearer term plan is to raise more funding — and potentially switch to offering the API for free to really scale up the data capture potential.

Zooming out for a little context, it’s been almost a decade since Google-backed Calico launched with the moonshot mission of ‘fixing death’. Since then a small but growing field of ‘longevity’ startups has sprung up, conducting research into extending (in the first instance) human lifespan. (Ending death is, clearly, the moonshot atop the moonshot.) 

Death is still with us, of course, but the business of identifying possible drugs and therapeutics to stave off the grim reaper’s knock continues picking up pace — attracting a growing volume of investor dollars.

The trend is being fuelled by health and biological data becoming ever more plentiful and accessible, thanks to open research data initiatives and the proliferation of digital devices and services for tracking health, set alongside promising developments in the fast-evolving field of machine learning in areas like predictive healthcare and drug discovery.

Longevity has also seen a bit of an upsurge in interest in recent times as the coronavirus pandemic has concentrated minds on health and wellness, generally — and, well, mortality specifically.

Nonetheless, it remains a complex, multi-disciplinary business. Some of these biotech moonshots are focused on bioengineering and gene-editing — pushing for disease diagnosis and/or drug discovery.

Plenty are also — like Gero —  trying to use AI and big data analysis to better understand and counteract biological ageing, bringing together experts in physics, maths and biological science to hunt for biomarkers to further research aimed at combating age-related disease and deterioration.

Another recent example is AI startup Deep Longevity, which came out of stealth last summer — as a spinout from AI drug discovery startup Insilico Medicine — touting an AI ‘longevity as a service’ system which it claims can predict an individual’s biological age “significantly more accurately than conventional methods” (and which it also hopes will help scientists to unpick which “biological culprits drive aging-related diseases”, as it put it).

Gero AI is taking a different tack toward the same overarching goal — by honing in on data generated by activity sensors embedded into the everyday mobile devices people carry with them (or wear) as a proxy signal for studying their biology.

The advantage being that it doesn’t require a person to undergo regular (invasive) blood tests to get an ongoing measure of their own health. Instead our personal device can generate proxy signals for biological study passively — at vast scale and low cost. So the promise of Gero’s ‘digital biomarkers’ is they could democratize access to individual health prediction.

And while billionaires like Peter Thiel can afford to shell out for bespoke medical monitoring and interventions to try to stay one step ahead of death, such high end services simply won’t scale to the rest of us.

If its digital biomarkers live up to Gero’s claims, its approach could, at the least, help steer millions towards healthier lifestyles, while also generating rich data for longevity R&D — and to support the development of drugs that could extend human lifespan (albeit what such life-extending pills might cost is a whole other matter).

The insurance industry is naturally interested — with the potential for such tools to be used to nudge individuals towards healthier lifestyles and thereby reduce payout costs.

For individuals who are motivated to improve their health themselves, Fedichev says the issue now is it’s extremely hard for people to know exactly which lifestyle changes or interventions are best suited to their particular biology.

For example fasting has been shown in some studies to help combat biological ageing. But he notes that the approach may not be effective for everyone. The same may be true of other activities that are accepted to be generally beneficial for health (like exercise or eating or avoiding certain foods).

Again those rules of thumb may have a lot of nuance, depending on an individual’s particular biology. And scientific research is, inevitably, limited by access to funding. (Research can thus tend to focus on certain groups to the exclusion of others — e.g. men rather than women; or the young rather than middle aged.)

This is why Fedichev believes there’s a lot of value in creating a measure than can address health-related knowledge gaps at essentially no individual cost.

Gero has used longitudinal data from the UK’s biobank, one of its research partners, to verify its model’s measurements of biological age and resilience. But of course it hopes to go further — as it ingests more data. 

“Technically it’s not properly different what we are doing — it just happens that we can do it now because there are such efforts like UK biobank. Government money and also some industry sponsors money, maybe for the first time in the history of humanity, we have this situation where we have electronic medical records, genetics, wearable devices from hundreds of thousands of people, so it just became possible. It’s the convergence of several developments — technological but also what I would call ‘social technologies’ [like the UK biobank],” he tells TechCrunch.

“Imagine that for every diet, for every training routine, meditation… in order to make sure that we can actually optimize lifestyles — understand which things work, which do not [for each person] or maybe some experimental drugs which are already proved [to] extend lifespan in animals are working, maybe we can do something different.”

“When we will have 1M tracks [half a year’s worth of data on 1M individuals] we will combine that with genetics and solve ageing,” he adds, with entrepreneurial flourish. “The ambitious version of this plan is we’ll get this million tracks by the end of the year.”

Fitness and health apps are an obvious target partner for data-loving longevity researchers — but you can imagine it’ll be a mutual attraction. One side can bring the users, the other a halo of credibility comprised of deep tech and hard science.

“We expect that these [apps] will get lots of people and we will be able to analyze those people for them as a fun feature first, for their users. But in the background we will build the best model of human ageing,” Fedichev continues, predicting that scoring the effect of different fitness and wellness treatments will be “the next frontier” for wellness and health (Or, more pithily: “Wellness and health has to become digital and quantitive.”)

“What we are doing is we are bringing physicists into the analysis of human data. Since recently we have lots of biobanks, we have lots of signals — including from available devices which produce something like a few years’ long windows on the human ageing process. So it’s a dynamical system — like weather prediction or financial market predictions,” he also tells us.

“We cannot own the treatments because we cannot patent them but maybe we can own the personalization — the AI that personalized those treatments for you.”

From a startup perspective, one thing looks crystal clear: Personalization is here for the long haul.


#ageing, #api, #apps, #artificial-intelligence, #biotech, #deep-neural-networks, #drug-development, #drug-discovery, #elon-musk, #gero-ai, #google, #health, #humanity-inc, #insilico-medicine, #insurance, #longevity, #machine-learning, #mobile, #mobile-devices, #peter-thiel, #russia, #science, #smartphones, #tc, #wearable-devices

How Long Can We Live?

New research is intensifying the debate — with profound implications for the future of the planet.

#elderly, #genetics-and-heredity, #longevity, #medicine-and-health, #research, #science-and-technology, #stem-cells

How the Human Life Span Doubled in 100 Years

Between 1920 and 2020, the average human life span doubled. How did we do it? Science mattered — but so did activism.

#antibiotics, #cholera, #coronavirus-risks-and-safety-concerns, #disease-rates, #epidemics, #fleming-alexander, #food-and-drug-administration, #infant-mortality, #influenza-epidemic-1918-19, #longevity, #milk, #montagu-mary-wortley, #pasteur-louis, #population, #salk-jonas-e, #smallpox, #statistics, #vaccination-and-immunization

A Graying China May Have to Put Off Retirement. Workers Aren’t Happy.

Most Chinese workers retire by 60. But with the population aging and pension funds running low, the government says that must change.

#china, #labor-and-jobs, #longevity, #pensions-and-retirement-plans, #retirement

Hester Ford, Oldest American, Dies

She was believed to be either 115 or 116. She experienced two pandemics and two world wars and lived under 21 presidents.

#deaths-obituaries, #ford-hester-1904-05-2021, #longevity

Your Smartphone Should Be Built to Last

A movement is underway to slow the obsolescence of our electronic gear.

#apple-inc, #computers-and-the-internet, #france, #hazardous-and-toxic-substances, #law-and-legislation, #longevity, #microsoft-corp, #new-york-state, #recycling-of-waste-materials, #samsung-group, #smartphones, #software, #sonos-inc, #sony-corporation, #states-us, #sustainable-living, #tablet-computers, #united-states

Looking Forward to Your 170th Birthday

In “Ageless,” Andrew Steele explores the science of aging and the advances that might let humans prolong their lives by decades.

#age-chronological, #ageless-the-new-science-of-getting-older-without-getting-old-book, #books-and-literature, #elderly, #longevity, #steele-andrew-author

If You Live to 100, You’ll Need More Than Money

The number of centenarians in the U.S. is growing steadily. If you join them, you’ll need not just a robust retirement fund but also a plan, and a purpose.

#content-type-service, #elderly, #longevity, #personal-finances, #retirement

Tom Brady, Defying Age, Heads to Another Super Bowl

The mother of the opposing Super Bowl LV quarterback was a year old when Brady was born. What’s he still doing here?

#brady-tom, #football, #longevity, #national-football-league, #super-bowl, #tampa-bay-buccaneers

Captain Tom, Who Raised Millions for U.K. Health Workers, Is Hospitalized

Tom Moore, 100, raised $40 million in the spring by walking laps in his garden. He was admitted to a hospital on Sunday with the coronavirus, his daughter said.

#coronavirus-2019-ncov, #great-britain, #longevity, #moore-tom-1920, #national-health-service, #philanthropy

Baby Megalodons Were 6-Foot-Long Womb Cannibals, Study Suggests

The research appears to confirm that, even as newborns, the extinct sharks were very, very big.

#longevity, #paleontology, #research, #sharks, #spine-body-part, #your-feed-science

How to Get More From Your Pandemic Bubble

Social bubbles have helped us cope with the restrictions of Covid-19. For today’s Well Challenge, look to your pandemic pod to inspire and motivate you toward a healthier and happier life.

#cooking-and-cookbooks, #diet-and-nutrition, #exercise, #friendship, #longevity, #quarantine-life-and-culture

When Did Republicans Start Hating Facts?

A straight line runs from Reagan to the Trump dead-enders.

#creationism-and-intelligent-design, #environment, #global-warming, #income-inequality, #longevity, #presidential-election-of-2020, #reagan-ronald-wilson, #trump-donald-j

Exercise 11 Minutes a Day for a Longer Life

The sweet spot for physical activity and longevity seemed to arrive at about 35 minutes a day of brisk walking or other moderate activities.

#exercise, #longevity

As They Became Seniors, They Started Businesses for Them

After working for others, some Americans find opportunities in working for themselves — while catering to people growing older.

#age-chronological, #content-type-service, #elderly, #entrepreneurship, #longevity, #retirement, #small-business