Researchers want to create “universal donor” lungs

Researchers want to create “universal donor” lungs

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In a plastic-domed case at the Toronto General Hospital Research Institute, researchers gave a pair of lungs a new identity. When the lungs first arrived in the lab, they were from someone with type A blood, meaning that there were certain tiny markers, called antigens, attached to the lung tissue and blood cells. But when the lungs left the lab, those antigens were almost entirely gone. In just one hour, the researchers had effectively transformed the lungs into type O.

“This is absolutely amazing,” says Aizhou Zhang, a researcher in the Cypel Lab at the University of Toronto and first author on a paper published this week in Science Translational Medicine that describes the transformation. The experiment is an important step toward giving more people access to life-saving organ transplants. More than 100,000 people in the United States are currently waiting for organs, but often those most in need can’t get help because of one big problem: their blood type doesn’t match the organs that are available.

Zhang works in a lab run by Marcelo Cypel, lead author on the paper and a thoracic surgeon who’s spent years figuring out ways to increase the number of lungs available for transplants. One of his previous innovations was creating ex vivo lung perfusion (EVLP), that plastic-domed apparatus in which this study’s lungs got their new identity.

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#healthcare, #human-organ-trans, #lungs, #organ-transplants, #science

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#coronavirus-2019-ncov, #hospitals, #lungs, #transplants

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The Risks of Another Epidemic: Teenage Vaping

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#coronavirus-2019-ncov, #hospitals, #lungs, #oxygen, #research, #respiratory-distress-syndrome, #therapy-and-rehabilitation, #ventilators-medical, #your-feed-healthcare

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Trump Says He’s Beaten Covid-19. Doctors Aren’t So Sure.

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#coronavirus-2019-ncov, #doctors, #hospitals, #lungs, #therapy-and-rehabilitation

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Breathe Better With These Nine Exercises

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#anxiety-and-stress, #apnea-sleep-disorder, #content-type-service, #lungs, #nose, #oxygen, #quarantine-life-and-culture

In Astounding Test, Scientists Revive Damaged Lungs for Transplant

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#columbia-university, #deaths-fatalities, #lungs, #nature-medicine-journal, #new-york-university-langone-medical-center, #pigs, #surgery-and-surgeons, #tissue-human, #transplants, #united-states, #university-of-toronto, #ventilators-medical, #vunjak-novakovic-gordana

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Coronavirus Attacks the Lungs. A Federal Agency Just Halted Funding for New Lung Treatments.

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#biomedical-advanced-research-and-development-authority, #clinical-trials, #coronavirus-2019-ncov, #dexamethasone-drug, #drugs-pharmaceuticals, #health-and-human-services-department, #lungs, #national-institutes-of-health, #research, #tests-medical, #trump-donald-j, #united-states-politics-and-government, #vaccination-and-immunization, #ventilators-medical, #your-feed-healthcare

She Struggled With Asthma, but It Had Never Been This Bad

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Covid-19 Patient Gets Double Lung Transplant, Offering Hope for Others

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#coronavirus-2019-ncov, #lungs, #northwestern-memorial-hospital-chicago-ill, #surgery-and-surgeons, #tissue-human, #transplants, #your-feed-healthcare

These Athletes Had the Coronavirus. Will They Ever Be the Same?

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#coronavirus-2019-ncov, #coronavirus-reopenings, #denver-broncos, #dybala-paulo-1993, #exercise, #juventus-soccer-team, #lungs, #miller-von, #running, #triathlon

A Virus-Hunter Falls Prey to a Virus He Underestimated

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#acquired-immune-deficiency-syndrome, #africa, #antwerp-belgium, #coalition-for-epidemic-preparedness-innovations, #coronavirus-2019-ncov, #ebola-virus, #epidemics, #immune-system, #international-aids-society, #london-england, #london-school-of-hygiene-and-tropical-medicine, #lungs, #oxygen, #piot-peter, #ramjee-gita, #sierra-leone, #singapore, #steroids, #unaids, #world-health-organization, #wuhan-china, #your-feed-health, #your-feed-science

Coronavirus May Pose a New Risk to Younger Patients: Strokes

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#blood-clots, #brain, #coronavirus-2019-ncov, #deep-vein-thrombosis, #emergency-medical-treatment, #fever, #hospitals, #lungs, #mount-sinai-medical-center, #new-england-journal-of-medicine, #new-york-city, #quarantines, #queens-nyc, #respiratory-distress-syndrome, #seizures-medical, #stroke, #therapy-and-rehabilitation, #ventilators-medical, #your-feed-science, #youth

Low-Tech Way to Help Some Covid Patients: Flip Them Over

Turning ventilated patients onto their stomachs, called proning, helps them by opening their lungs. Now doctors are testing to see if it can keep others off ventilators altogether.

#clinical-trials, #coronavirus-2019-ncov, #epidemics, #hospitals, #lungs, #montefiore-health-system, #oxygen, #respiratory-distress-syndrome, #rush-university-medical-center, #ventilators-medical, #your-feed-science

Children Gravely Ill With Covid-19 Often Had Other Medical Conditions

A study of 48 young I.C.U. patients in U.S. hospitals found that two died. Eighteen of the children were put on ventilators.

#children-and-childhood, #coronavirus-2019-ncov, #deaths-fatalities, #epidemics, #hospitals, #jama-pediatrics-journal, #lungs, #united-states, #ventilators-medical, #your-feed-healthcare

32 Days on a Ventilator: One Covid Patient’s Fight to Breathe Again

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#coronavirus-2019-ncov, #hospitals, #lungs, #massachusetts-general-hospital, #medical-devices, #oxygen, #respiratory-distress-syndrome, #ventilators-medical, #your-feed-science

Coronavirus Tips: Do Not Ingest or Inject Disinfectant

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#cleansers-detergents-and-soaps, #coronavirus-2019-ncov, #lungs, #poisoning-and-poisons, #shortages, #sunlight, #ultraviolet-light, #white-house-building-washington-dc

Fears of Ventilator Shortage During Coronavirus Pandemic Unleash a Wave of Innovations

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#coronavirus-2019-ncov, #hospitals, #lungs, #medical-devices, #north-shore-university-hospital, #oxygen, #ventilators-medical

Asthma Is Absent Among Top Covid-19 Risk Factors, Early Data Shows

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Stay 6 Feet Apart, We’re Told. But How Far Can Air Carry Coronavirus?

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#centers-for-disease-control-and-prevention, #coronavirus-2019-ncov, #lungs, #nose, #physics, #research, #respiratory-diseases, #respiratory-system, #your-feed-healthcare, #your-feed-science

Smokers and Vapers May Be at Greater Risk for Covid-19

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#coronavirus-2019-ncov, #e-cigarettes, #lungs, #smoking-and-tobacco, #teenagers-and-adolescence, #your-feed-science

How to Take Care of Your Lungs

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#air-pollution, #asthma, #chronic-obstructive-pulmonary-disease, #coronavirus-2019-ncov, #environment, #global-warming, #lungs