High-bandwidth wireless BCI demonstrated in humans for first time

Stylized image of a brain with in a human head.

Enlarge / The BrainGate research consortium has achieved the first human use of a high-bandwidth, wireless brain-computer interface, enabling tetraplegic participants in a clinical trial to use the device without being tethered by a cable. (credit: kentoh/iStock/Getty Images)

Coming on the heels of the Neuralink announcement earlier this month—complete with video showing a monkey playing Pong with its mind, thanks to a wireless brain implant—researchers with the BrainGate Consortium has successfully demonstrated a high-bandwidth wireless brain-computer interface (BCI) in two tetraplegic human subjects. The researchers described their work in a recent paper published in the journal IEEE Transactions in Biomedical Engineering.

BCIs interact with brain cells, recording the electrical activity of neurons and translating those signals into action. Such systems generally involve electrode sensors to record neuronal activity, a chipset to transmit the signals, and computer algorithms to translate the signals. BCIs can be external, similar to medical EEGs in that the electrodes are placed onto the scalp or forehead with a wearable cap; or they can be implanted directly into the brain. The former are less invasive but can be less accurate because there is more noise interfering with the signals; the latter require brain surgery, which can be risky.

BrainGate is an implanted device, used in research efforts focused on treating patients with spinal cord injuries or Lou Gehrig’s disease. Back in 2012, two paralyzed subjects with BrainGate implants successfully controlled a robotic arm; since then, subjects have been able to type on computers and use tablet apps. That BrainGate system employs a large, gray box cable, tethering the implanted sensor array to the external computers that decode the signals. This has restricted the system’s usefulness because technicians need to be on site during operation and take the cable with them when they finish a session.

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#bci, #brain-computer-interface, #braingate, #medical-devices, #neuralink, #neuroscience, #science

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Many Older Adults Lack Even Simple, Helpful Equipment

Railings, grab bars, shower chairs and other inexpensive devices can make it easier to continue living at home, but not enough older people acquire them.

#disabilities, #elderly, #home-repairs-and-improvements, #medical-devices, #therapy-and-rehabilitation, #your-feed-health, #your-feed-science

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How Policy Changes and Innovation Could Bring Hearing Aids for the Masses

Relatively simple technology and a change in government policy could unleash more innovation for Americans who have difficulty hearing.

#computers-and-the-internet, #food-and-drug-administration, #hearing-aids, #medical-devices

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‘There Was Nothing Anybody Could Do for These Patients.’ Now There Is.

The first successful direct transplant of a trachea is a medical milestone that could help thousands of people with airways damaged by ventilators and other causes.

#genden-eric-m-sr, #macchiarini-paolo, #medical-devices, #mount-sinai-medical-center, #neck, #organ-donation, #surgery-and-surgeons, #trachea, #transplants, #your-feed-science

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How Rani Therapeutics’ robotic pill could change subcutaneous injection treament

A new auto-injecting pill might soon become a replacement for subcutaneous injection treatments.

The idea for this so-called robotic pill came out of a research project around eight years ago from InCube Labs—a life sciences lab operated by Rani Therapeutics Chairman and CEO Mir Imran, who has degrees in electrical and biomedical engineering from Rutgers University. A prominent figure in life sciences innovation, Imran has founded over 20 medical device companies and helped develop the world’s first implantable cardiac defibrillator.

In working on the technology behind San Jose-based Rani Therapeutics, Imran and his team wanted to find a way to relieve some of the painful side effects of subcutaneous (or under-the-skin) injections, while also improving the treatment’s efficacy. “The technology itself started with a very simple thesis,” said Imran in an interview. “We thought, why can’t we create a pill that contains a biologic drug that you swallow, and once it gets to the intestine, it transforms itself and delivers a pain-free injection?”

Rani Therapeutics’ approach is based on inherent properties of the gastrointestinal tract. An injecting mechanism in their pill is surrounded by a pH-sensitive coating that dissolves as the capsule moves from a patient’s stomach to the small intestine. This helps ensure that the pill starts injecting the medicine in the right place at the right time. Once there, the reactants mix and produce carbon dioxide, which in turn inflates a small balloon that helps create a pressure difference to help inject the drug-loaded needles into the intestinal wall. “So it’s a really well-timed cascade of events that results in the delivery of this needle,” said Imran.

Despite its somewhat mechanical procedure, the pill itself contains no metal or springs, reducing the chance of an inflammatory response in the body. The needles and other components are instead made of injectable-grade polymers, that Imran said has been used in other medical devices as well. Delivering the injections to the upper part of the small intestine also carries little risk of infection, as the prevalence of stomach acid and bile from the liver prevent bacteria from readily growing there.

One of Imran’s priorities for the pill was to eliminate the painful side effects of subcutaneous injections. “It wouldn’t make sense to replace them with another painful injection,” he said. “But biology was on our side, because your intestines don’t have the kind of pain sensors your skin does.” What’s more, administering the injection into the highly vascularized wall of the small intestine actually allows the treatment to work more efficiently than when applied through subcutaneous injection, which typically deposits the treatment into fatty tissue.

Imran and his team have plans to use the pill for a variety of indications, including the growth hormone disorder acromegaly, diabetes, and osteoporosis. In January 2020, their acromegaly treatment, Octreotide, demonstrated both safety and sustained bioavailability in primary clinical trials. They hope to pursue future clinical trials for other indications, but chose to prioritize acromegaly initially because of its well-established treatment drug but “very painful injection,” Imran said.

At the end of last year, Rani Therapeutics raised $69 million in new funding to help further develop and test their platform. “This will finance us for the next several years,” said Imran. “Our approach to the business is to make the technology very robust and manufacturable.”

#biotech, #diabetes, #health, #infection, #medical-devices, #pain, #recent-funding, #robotics, #rutgers-university, #san-jose, #science, #startups, #therapeutics

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Covid-19 in Mexico: Oxygen Shortage Leaves Many to Die at Home

With hospitals overrun, Mexicans fighting the coronavirus at home face a deadly hurdle: a lack of oxygen tanks.

#coronavirus-2019-ncov, #medical-devices, #medicine-and-health, #mexico, #oxygen, #shortages

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Why Should China Make Everything?

The United States can bring manufacturing back — which will bring back good jobs and protect national interests.

#5g-wireless-communications, #biden-joseph-r-jr, #factories-and-manufacturing, #labor-and-jobs, #medical-devices, #shortages, #united-states, #united-states-economy

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New York Spent $1 Billion on Virus Supplies. Now It Wants Money Back.

City and state officials are trying to recover millions from quick deals made during the worst weeks of the pandemic this spring.

#coronavirus-2019-ncov, #cuomo-andrew-m, #medical-devices, #new-york-city, #new-york-state, #politics-and-government, #suits-and-litigation-civil, #ventilators-medical

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A.I. and I

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#artificial-intelligence, #computers-and-the-internet, #diabetes, #medical-devices

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Baricitinib: Doctors Are Skeptical of This Covid-19 Drug From Eli Lilly

Baricitinib, an arthritis drug made by Eli Lilly, may reduce recovery time by a day, but costs about $1,500 and comes with side effects.

#clinical-trials, #dexamethasone-drug, #drugs-pharmaceuticals, #medical-devices, #research, #steroids

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The U.S. Has Lots of Ventilators — but Too Few Specialists to Mind Them

A burst of production solved the dire shortage that defined the first wave of the coronavirus. But the surplus may not be enough to prevent large numbers of deaths.

#coronavirus-2019-ncov, #deaths-fatalities, #defense-production-act, #hospitals, #medical-devices, #medicine-and-health, #oxygen, #shortages, #states-us, #stockpiling, #trump-donald-j, #ventilators-medical, #your-feed-healthcare

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These Algorithms Could End the Scourge of Tuberculosis

In rural India and other places where tuberculosis is rampant, A.I. that scans lung X-rays might eliminate the scourge.

#artificial-intelligence, #hospitals, #india, #medical-devices, #mobile-applications, #qure-ai, #qxr-mobile-app, #respiratory-diseases, #rural-areas, #shortages, #tests-medical, #tuberculosis, #x-rays, #your-feed-science

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Inside the Chaotic, Cutthroat Gray Market for N95 Masks

As the country heads into a dangerous new phase of the pandemic, the government’s management of the P.P.E. crisis has left the private sector still straining to meet anticipated demand.

#coronavirus-2019-ncov, #defense-production-act, #factories-and-manufacturing, #government-contracts-and-procurement, #international-trade-and-world-market, #masks, #medical-devices, #medicine-and-health, #protective-clothing-and-gear, #shortages, #stockpiling, #united-states-politics-and-government

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Hiker Rescued From Mount Rainier Makes ‘Miraculous’ Recovery

When Michael Knapinski arrived at a Seattle hospital, his heart stopped for 45 minutes and he was put on life support. Two days later, he was walking.

#emergency-medical-treatment, #hikes-and-hiking, #hospitals, #life-sustaining-support-systems-withdrawal-of, #medical-devices, #mount-rainier-wash, #national-parks-monuments-and-seashores, #nursing-and-nurses, #seattle-wash, #ventilators-medical

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#computer-security, #computers-and-the-internet, #coronavirus-2019-ncov, #cyberattacks-and-hackers, #hospitals, #medical-devices

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#china, #coronavirus-2019-ncov, #forced-labor, #medical-devices, #uighurs-chinese-ethnic-group, #united-states, #xinjiang-china

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China Dominates P.P.E. Manufacturing

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#china, #coronavirus-2019-ncov, #factories-and-manufacturing, #international-trade-and-world-market, #masks, #medical-devices, #protective-clothing-and-gear, #sinopec-corp

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#black-people, #discrimination, #doctors, #jones-david-s-scholar, #kidneys, #medical-devices, #medicine-and-health, #new-england-journal-of-medicine, #race-and-ethnicity, #research

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#coronavirus-2019-ncov, #drugs-pharmaceuticals, #immune-system, #medical-devices

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#3m-company, #centers-for-disease-control-and-prevention, #china, #coronavirus-2019-ncov, #food-and-drug-administration, #masks, #medical-devices, #national-institute-for-occupational-safety-and-health, #shortages, #your-feed-healthcare

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Coronavirus Meets a Drive to End Malnutrition in Africa

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#africa, #british-broadcasting-corp, #children-and-childhood, #coronavirus-2019-ncov, #coronavirus-reopenings, #dar-es-salaam-tanzania, #diet-and-nutrition, #flour, #food, #france, #geneva-switzerland, #germany, #grain, #iodine, #iron-nutrient, #magufuli-john-1959, #malnutrition, #masks, #medical-devices, #project-healthy-children, #shutdowns-institutional, #small-business, #spina-bifida, #stanford-university, #united-states-agency-for-international-development, #ventilators-medical, #vitamin-b12, #vitamins, #world-food-program

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We Treated Older Coronavirus Patients. Here’s How to Save More of Them.

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#aoyagi-takuo, #centers-for-disease-control-and-prevention, #coronavirus-2019-ncov, #italy, #medical-devices, #new-york-city, #nursing-homes, #pneumonia, #pulse-oximetry, #ventilators-medical

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Israeli Army’s Idea Lab Aims at a New Target: Saving Lives

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#artificial-intelligence, #coronavirus-2019-ncov, #defense-and-military-forces, #israel, #medical-devices, #microbiology, #telemedicine, #ventilators-medical

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How Kushner’s Volunteer Force Led a Fumbling Hunt for Medical Supplies

Roughly a dozen young, inexperienced workers were assembled to sort through tips on masks, gloves and other equipment. Warehouses were running bare, and doctors fighting the coronavirus were forced to make their own protective gear.

#coronavirus-2019-ncov, #defense-production-act, #federal-emergency-management-agency, #government-contracts-and-procurement, #kushner-jared, #masks, #medical-devices, #trump-donald-j, #united-states-politics-and-government

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Find a Vaccine. Next: Produce 300 Million Vials of It.

Scaling up the manufacturing of syringes and other medical products required to deliver a vaccine to millions of Americans will be just as important as the vaccine itself.

#biomedical-advanced-research-and-development-authority, #coronavirus-2019-ncov, #epidemics, #factories-and-manufacturing, #federal-emergency-management-agency, #hypodermic-needles-and-syringes, #medical-devices, #medicine-and-health, #shortages, #vaccination-and-immunization, #your-feed-healthcare

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32 Days on a Ventilator: One Covid Patient’s Fight to Breathe Again

Jim Bello, 49 and healthy, fell gravely ill, highlighting agonizing mysteries of the coronavirus. Doctors’ relentless effort to save him was a roller-coaster of devastating and triumphant twists.

#coronavirus-2019-ncov, #hospitals, #lungs, #massachusetts-general-hospital, #medical-devices, #oxygen, #respiratory-distress-syndrome, #ventilators-medical, #your-feed-science

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One Rich N.Y. Hospital Got Warren Buffett’s Help. This One Got Duct Tape.

The inequities of New York City’s health care system are clear at a public hospital in a section of Brooklyn hit hard by the coronavirus pandemic.

#brooklyn-nyc, #colleges-and-universities, #coronavirus-2019-ncov, #deaths-fatalities, #hospitals, #masks, #medical-devices, #mount-sinai-medical-center, #nursing-and-nurses, #protective-clothing-and-gear, #state-university-of-new-york, #university-hospital-of-brooklyn, #ventilators-medical, #wayne-j-riley, #workplace-hazards-and-violations

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Here’s How You Can Help People During the Coronavirus

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#coronavirus-2019-ncov, #hygiene-and-cleanliness, #medical-devices, #native-americans, #philanthropy, #poverty, #refugees-and-displaced-persons, #shortages, #third-world-and-developing-countries, #water

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China’s Elite Donate Coronavirus Gear to the U.S.

People and companies with vested interest in sustaining the U.S.-China relationship are stepping in as ties fray between the two countries.

#alibaba-group-holding-ltd, #asia-society, #benioff-marc, #china, #china-international-trustinvestment-corp, #citic-capital, #coronavirus-2019-ncov, #corporate-social-responsibility, #factories-and-manufacturing, #high-net-worth-individuals, #ma-jack, #masks, #medical-devices, #politics-and-government, #protective-clothing-and-gear, #quarantines, #salesforce-com-inc, #shortages, #tsai-joseph-c, #united-states-international-relations, #united-states-politics-and-government, #zhang-daniel-1972

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This Pandemic Is Bringing Another With It

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#children-and-childhood, #coronavirus-2019-ncov, #epidemics, #hygiene-and-cleanliness, #medical-devices, #poverty, #quarantines, #shortages, #shutdowns-institutional, #third-world-and-developing-countries, #world-bank, #world-food-program

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NY Needed Ventilators for Coronavirus. They Developed One in a Month.

The pandemic inspired an innovative project to design and make a low-cost ventilator in weeks, not years.

#boyce-technologies-inc, #computers-and-the-internet, #coronavirus-2019-ncov, #engineering-and-engineers, #epidemics, #factories-and-manufacturing, #marcel-botha, #massachusetts-institute-of-technology, #medical-devices, #scott-cohen, #shortages, #spiro-wave, #ventilators-medical

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Fears of Ventilator Shortage During Coronavirus Pandemic Unleash a Wave of Innovations

Hair dryer hoods, sleep apnea machines and simply flipping patients on their stomach have helped sustain patients and reduced the need for critical care ventilators.

#coronavirus-2019-ncov, #hospitals, #lungs, #medical-devices, #north-shore-university-hospital, #oxygen, #ventilators-medical

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Trump’s Coronavirus Tactics Hurt Cubans, Too

For once, some Cubans look north and commiserate with Americans, even as Washington prevents needed help from reaching their island.

#coronavirus-2019-ncov, #cuba, #do-it-yourself, #economic-conditions-and-trends, #embargoes-and-sanctions, #europe, #granma-newspaper, #havana-cuba, #italy, #medical-devices, #new-jersey, #quarantines, #shortages, #shutdowns-institutional, #social-media, #state-department, #trump-donald-j, #united-nations, #united-states, #united-states-politics-and-government

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People Are Dying and All Britain Can Talk About Is Boris Johnson

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#conservative-party-great-britain, #coronavirus-2019-ncov, #great-britain, #great-britain-withdrawal-from-eu-brexit, #johnson-boris, #medical-devices, #politics-and-government

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A Coronavirus Pandemic Is No Time to Let the Market Decide

When it comes to crucial medical supplies, cooperation, not competition, will save lives. History shows that it works.

#coronavirus-2019-ncov, #economic-conditions-and-trends, #epidemics, #european-union, #international-trade-and-world-market, #league-of-nations, #medical-devices, #protective-clothing-and-gear, #tedros-adhanom-ghebreyesus, #wilson-woodrow, #world-health-organization, #world-war-i-1914-18

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What Doctors on the Front Lines Wish They’d Known a Month Ago

Ironclad emergency medical practices — about when to use ventilators, for example — have dissolved almost overnight.

#coronavirus-2019-ncov, #doctors, #hospitals, #medical-devices, #new-york-metropolitan-area, #ventilators-medical

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The Pandemic Proves the Need for Industrial Policy

The president has promoted himself as a champion of American manufacturing, but now he avoids addressing its shortcomings.

#anheuser-busch-inbev-nv, #apple-inc, #biden-joseph-r-jr, #cnbc, #coronavirus-2019-ncov, #coronavirus-aid-relief-and-economic-security-act-2020, #corporate-social-responsibility, #defense-production-act, #executive-orders-and-memorandums, #factories-and-manufacturing, #house-of-representatives, #international-trade-and-world-market, #masks, #medical-devices, #medicine-and-health, #protective-clothing-and-gear, #shortages, #trump-donald-j, #united-states-politics-and-government, #united-steelworkers-of-america, #ventilators-medical

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Putin’s Bleak Covid-19 Admission: ‘We Don’t Have Much to Brag About’

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#coronavirus-2019-ncov, #hospitals, #medical-devices, #moscow-russia, #putin-vladimir-v, #russia, #sobyanin-sergei-s

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Israel’s Not-So-Secret Weapon in Coronavirus Fight: The Spies of Mossad

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#cohen-yossi-1961, #coronavirus-2019-ncov, #israel, #medical-devices, #medicine-and-health, #mossad, #shortages

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Life and Death as Hospitals Fight the Coronavirus in the Bronx

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#bronx-nyc, #coronavirus-2019-ncov, #deaths-fatalities, #emergency-medical-treatment, #epidemics, #medical-devices, #montefiore-medical-center, #nursing-and-nurses, #protective-clothing-and-gear, #shortages, #ventilators-medical

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Virus Deaths Mount, but N.Y. Avoids Predicted Surge at Hospitals So Far

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#coronavirus-2019-ncov, #cuomo-andrew-m, #deaths-fatalities, #hospitals, #institute-for-health-metrics-and-evaluation, #medical-devices, #new-york-state, #statistics, #united-states-politics-and-government, #ventilators-medical

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Global Trade Sputters, Leaving Too Much Here, Too Little There

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#azevedo-roberto, #coronavirus-2019-ncov, #dairy-products, #drugs-pharmaceuticals, #factories-and-manufacturing, #international-trade-and-world-market, #laptop-computers, #medical-devices, #ships-and-shipping, #shortages, #world-trade-organization

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‘Swept Up by FEMA’: Complicated Medical Supply System Sows Confusion

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#coronavirus-2019-ncov, #federal-emergency-management-agency, #federal-state-relations-us, #health-and-human-services-department, #medical-devices, #protective-clothing-and-gear, #shortages, #states-us, #stockpiling, #united-states-politics-and-government, #ventilators-medical

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Red States Are Exploiting Coronavirus to Ban Abortion

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#abbott-gregory-w-1957, #abortion, #coronavirus-2019-ncov, #epidemics, #governors-us, #medical-devices, #planned-parenthood-federation-of-america, #pregnancy-and-childbirth, #republican-party, #roe-v-wade-supreme-court-decision, #states-us, #texas, #women-and-girls

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A Ventilator Stockpile, With One Hitch: Thousands Do Not Work

While President Trump has assured states that thousands of ventilators remain at the ready, thousands more are in storage, unmaintained or otherwise unusable.

#agiliti, #coronavirus-2019-ncov, #federal-emergency-management-agency, #health-and-human-services-department, #medical-devices, #states-us, #stockpiling, #trump-donald-j, #united-states-politics-and-government, #ventilators-medical, #vyaire-medical

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Iran, Devastated by Coronavirus, Says U.S. Sanctions Are Taking Lives

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#coronavirus-2019-ncov, #embargoes-and-sanctions, #epidemics, #european-union, #house-of-representatives, #human-rights-watch, #humanitarian-aid, #international-crisis-group, #international-monetary-fund, #iran, #khamenei-ali, #medical-devices, #murphy-christopher-scott, #politics-and-government, #pompeo-mike, #sanders-bernard, #state-department, #united-states-international-relations, #united-states-politics-and-government, #ventilators-medical, #zarif-mohammad-javad

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Defense Production Act Has Been Used Routinely, but Not With Coronavirus

The Defense Production Act has been invoked hundreds of thousands of times in the Trump years. But with the pandemic, the president sees it as a “break the glass” last resort.

#coronavirus-2019-ncov, #defense-department, #defense-production-act, #disasters-and-emergencies, #federal-emergency-management-agency, #general-motors, #government-contracts-and-procurement, #law-and-legislation, #medical-devices, #nationalization-of-industry, #protective-clothing-and-gear, #shortages, #stockpiling, #tests-medical, #trump-donald-j, #united-states-politics-and-government, #ventilators-medical

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Why the U.S. Is Running Out of Medical Supplies

Health care is a private industry in the U.S., and hospitals are businesses designed to maximize profit, not respond to a pandemic.

#coronavirus-2019-ncov, #health-insurance-and-managed-care, #medical-devices, #shortages, #stockpiling, #united-states, #ventilators-medical

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Coronavirus Live Updates: Trump Signs $2 Trillion Relief Bill

President Trump, who had questioned the need for additional ventilators, pushes industry to make more. A new survey of mayors finds dire shortages of urgently needed medical supplies. And in Britain, Prime Minister Boris Johnson tested positive.

#birx-deborah-l, #california, #coronavirus-2019-ncov, #cuomo-andrew-m, #medical-devices, #new-york-state, #stimulus-economic, #trump-donald-j, #united-states, #united-states-international-relations

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‘The Other Option Is Death’: New York Starts Sharing of Ventilators

To keep coronavirus patients breathing, hospitals are pioneering a little-tested method.

#american-lung-assn, #coronavirus-2019-ncov, #hospitals, #medical-devices, #medicine-and-health, #new-york-presbyterian-hospital, #ventilators-medical, #your-feed-science

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