Pfizer Seeks Authorization of a Second Booster Shot for Older Americans

The move could further inflame a tortuous debate among scientists over when the coronavirus vaccines’ protection should be bolstered, and for whom.

#biontech-se, #centers-for-disease-control-and-prevention, #coronavirus-2019-ncov, #elderly, #food-and-drug-administration, #national-institutes-of-health, #pfizer-inc, #research, #vaccination-and-immunization

Vacancies in Top Health and Science Jobs May Threaten Biden’s Agenda

President Biden came into office vowing to respect science, but openings in crucial jobs could hamper progress on medical and technological research.

#becerra-xavier, #biden-joseph-r-jr, #califf-robert-m, #centers-for-disease-control-and-prevention, #coronavirus-2019-ncov, #defense-advanced-research-projects-agency, #food-and-drug-administration, #health-and-human-services-department, #lander-eric-s, #national-institutes-of-health, #research, #science-and-technology, #united-states-politics-and-government, #woodcock-janet

The C.D.C.’s New Challenge? Grappling With Imperfect Science

The Omicron coronavirus variant is moving much faster than researchers can, worsening a longstanding problem: The agency must make tough decisions with scant data.

#centers-for-disease-control-and-prevention, #coronavirus-2019-ncov, #coronavirus-omicron-variant, #national-institutes-of-health, #quarantines, #walensky-rochelle, #your-feed-science

How The mRNA Vaccines Were Made: Halting Progress and Happy Accidents

The stunning Covid vaccines manufactured by Pfizer-BioNTech and Moderna drew upon long-buried discoveries made in the hopes of ending past epidemics.

#acquired-immune-deficiency-syndrome, #clinical-trials, #coronavirus-2019-ncov, #fauci-anthony-s, #graham-barney-s-1953, #kariko-katalin-1955, #mers-middle-east-respiratory-syndrome, #national-institutes-of-health, #vaccination-and-immunization, #weissman-drew-1961, #your-feed-science

Cannabis to Help You Diet? One Edibles Company Thinks So

An edibles company says one of its products will lead not to the “the munchies” but to weight loss. There’s just one problem: the science.

#advertising-and-marketing, #cannabis-foods-and-products, #clinical-trials, #colorado, #drug-enforcement-administration, #food-and-drug-administration, #marijuana, #medical-marijuana, #national-institutes-of-health, #science-and-technology, #university-of-mississippi

Family in Nigeria Lost 3 Daughters to Sickle Cell. Can They Save a Fourth?

About 150,000 babies are born each year in Nigeria with sickle cell, a deadly disease. Tens of thousands of them die annually before their fifth birthdays.

#africa, #blood, #children-and-childhood, #deaths-fatalities, #debaun-michael-r, #drugs-pharmaceuticals, #genetics-and-heredity, #kano-nigeria, #lancet-the-journal, #national-institutes-of-health, #nigeria, #sickle-cell-anemia, #stroke, #tests-medical

Overturning Roe Will Make Miscarriage Care Worse

The worst day of your life could become more painful and more dangerous.

#abortion, #gynecology-and-gynecologists, #internal-sub-only-nl, #miscarriages, #national-institutes-of-health, #parenting, #planned-parenthood-federation-of-america, #pregnancy-and-childbirth, #roman-catholic-church, #supreme-court-us

Moderna and U.S. at Odds Over Vaccine Patent Rights

Moderna’s patent application names several employees as the sole inventors of a crucial component of its coronavirus vaccine, excluding three government scientists.

#bancel-stephane, #corbett-kizzmekia-s, #coronavirus-2019-ncov, #drugs-pharmaceuticals, #graham-barney-s-1953, #inventions-and-patents, #mascola-john-r, #moderna-inc, #national-institutes-of-health, #patent-and-trademark-office-us, #research, #science-and-technology, #vaccination-and-immunization

N.I.H. Says Bat Research Group Failed to Submit Prompt Virus Findings

The federal agency told a G.O.P. House member that it had notified EcoHealth Alliance, a group criticized for its U.S.-funded work with Wuhan scientists, to file data within five days.

#collins-francis-s, #comer-james-r, #coronavirus-2019-ncov, #ecohealth-alliance, #national-institutes-of-health, #republican-party, #research, #united-states-politics-and-government, #viruses, #wuhan-institute-of-virology-china

F.D.A. to Allow ‘Mix and Match’ Approach for Covid Booster Shots

The agency may act this week, when it is expected to authorize booster shots for recipients of the Moderna and Johnson & Johnson vaccines.

#centers-for-disease-control-and-prevention, #coronavirus-2019-ncov, #food-and-drug-administration, #johnsonjohnson, #moderna-inc, #national-institutes-of-health, #pfizer-inc, #regulation-and-deregulation-of-industry, #united-states-politics-and-government, #vaccination-and-immunization

Data from Federal Scientists Raise Questions About J.&J. Booster Shots

People who have received the company’s one-shot vaccine may benefit from a booster with another brand. F.D.A. advisers will discuss the data on Friday.

#clinical-trials, #coronavirus-2019-ncov, #coronavirus-delta-variant, #food-and-drug-administration, #johnsonjohnson, #moderna-inc, #national-institutes-of-health, #pfizer-inc, #research, #united-states-politics-and-government, #vaccination-and-immunization, #your-feed-healthcare

Francis Collins, Who Guided N.I.H. Through Covid-19 Crisis, Is Exiting

The agency’s director under three presidents said he was planning to shift his focus back to the lab, and that he hoped his replacement would be a woman.

#appointments-and-executive-changes, #biden-joseph-r-jr, #collins-francis-s, #coronavirus-2019-ncov, #fauci-anthony-s, #national-institutes-of-health, #united-states-politics-and-government

N.I.H. Director to Step Down by the End of 2021

The agency’s director under three presidents said he was planning to shift his focus back to the lab, and that he hoped his replacement would be a woman.

#appointments-and-executive-changes, #biden-joseph-r-jr, #collins-francis-s, #coronavirus-2019-ncov, #fauci-anthony-s, #national-institutes-of-health, #united-states-politics-and-government

Dr. Fauci, Movie Star

“Fauci,” a new documentary, follows his work in two health crises: AIDS and the coronavirus pandemic. He agreed to participate as long as it didn’t interfere with his work.

#coronavirus-2019-ncov, #documentary-films-and-programs, #fauci-anthony-s, #movies, #national-institute-of-allergy-and-infectious-diseases, #national-institutes-of-health

F.D.A. Panel Recommends Pfizer Boosters for Those Over 65 or at Risk

The committee said there was insufficient evidence to recommend third shots for all adult recipients of the vaccine, as Pfizer had requested.

#centers-for-disease-control-and-prevention, #coronavirus-2019-ncov, #food-and-drug-administration, #moderna-inc, #national-institutes-of-health, #pfizer-inc, #united-states, #united-states-politics-and-government, #vaccination-and-immunization

Health Officials Advise White House to Scale Back Booster Plan for Now

Federal regulators warned on Thursday they may not have enough data to recommend boosters for anyone except certain recipients of the Pfizer vaccine by late September.

#centers-for-disease-control-and-prevention, #coronavirus-2019-ncov, #food-and-drug-administration, #johnsonjohnson, #moderna-inc, #national-institutes-of-health, #pfizer-inc, #united-states-politics-and-government, #vaccination-and-immunization

Headache Research Advances Though Cures Are Elusive

Research into these often mysterious and debilitating disorders has languished. That’s changing.

#amgen-inc, #brain, #clinical-trials, #denmark, #drugs-pharmaceuticals, #eli-lilly-and-company, #food-and-drug-administration, #headaches, #health-insurance-and-managed-care, #migraine-headaches, #national-institutes-of-health, #nerves-and-nervous-system, #pain, #research, #science-and-technology, #united-states

Anthony Fauci on the Lab Leak Theory and Emailing Mark Zuckerberg

America’s chief immunologist claps back.

#audio-neutral-informative, #coronavirus-2019-ncov, #fauci-anthony-s, #national-institutes-of-health, #vaccination-and-immunization

A Pill to Treat Covid-19? The U.S. Is Betting on It.

A new $3.2 billion program will support the development of antiviral pills, which could start arriving by the end of this year.

#clinical-trials, #coronavirus-2019-ncov, #drugs-pharmaceuticals, #national-institutes-of-health, #remdesivir-drug, #your-feed-healthcare

Scientists Report Earliest Known Coronavirus Cases in Five US States

Blood drawn from nine people in the earliest days of the pandemic tested positive for the infection. But some experts questioned the results.

#antibodies, #blood-donation, #china, #clinical-infectious-diseases-journal, #coronavirus-2019-ncov, #disease-rates, #illinois, #massachusetts, #mississippi, #national-institutes-of-health, #pennsylvania, #states-us, #united-states, #wisconsin, #your-feed-science

Scientists Report Earliest Known Coronavirus Infections in Five U.S. States

Blood drawn from nine people in the earliest days of the pandemic tested positive for the infection. But some experts questioned the results.

#antibodies, #blood-donation, #china, #clinical-infectious-diseases-journal, #coronavirus-2019-ncov, #disease-rates, #illinois, #massachusetts, #mississippi, #national-institutes-of-health, #pennsylvania, #states-us, #united-states, #wisconsin, #your-feed-science

These Sisters With Sickle Cell Had Devastating — and Preventable — Strokes

Kyra and Kami never got a simple test that could have protected them. Their story exemplifies the failure to care for people with the disease, most of whom are Black.

#black-people, #children-and-childhood, #doctors, #genetics-and-heredity, #national-institutes-of-health, #preventive-medicine, #race-and-ethnicity, #sickle-cell-anemia, #stroke, #tests-medical, #transfusions, #ultrasonic-imaging-and-sonograms

America’s Next Move? Vaccinate the World.

Vaccinating the world is possible. The United States should lead the way. 

#biden-joseph-r-jr, #coronavirus-2019-ncov, #national-institutes-of-health, #united-states, #vaccination-and-immunization, #world-health-organization

C.D.C. Chief Defends Pandemic Guidance as Impatience Mounts

At a Senate hearing on the federal government’s pandemic response, Republicans criticized the government’s guidance for cruise ships, fishermen, summer camps and outdoor mask wearing.

#centers-for-disease-control-and-prevention, #coronavirus-2019-ncov, #coronavirus-reopenings, #coronavirus-risks-and-safety-concerns, #disease-rates, #national-institutes-of-health, #united-states-politics-and-government, #vaccination-and-immunization

Biden proposes ARPA-H, a health research agency to ‘end cancer’ modeled after DARPA

In a joint address to Congress last night, President Biden updated the nation on vaccination efforts and outlined his administration’s ambitious goals.

Biden’s first 100 days have been characterized by sweeping legislative packages that could lift millions of Americans out of poverty and slow the clock on the climate crisis, but during his first joint address to Congress, the president highlighted another smaller plan that’s no less ambitious: to “end cancer as we know it.”

“I can think of no more worthy investment,” Biden said Wednesday night. “I know of nothing that is more bipartisan…. It’s within our power to do it.”

The comments weren’t out of the blue. Earlier this month, the White House released a budget request for $6.5 billion to launch a new government agency for breakthrough health research. The proposed health agency would be called ARPA-H and would live within the NIH. The initial focus would be on cancer, diabetes and Alzheimer’s but the agency would also pursue other “transformational innovation” that could remake health research.

The $6.5 billion investment is a piece of the full $51 billion NIH budget. But some critics believe that ARPA-H should sit under the Department of Health and Human Services rather than being nested under NIH. 

ARPA-H would be modeled after the Defense Advanced Research Projects Agency (DARPA), which develops moonshot-like tech for defense applications. DARPA’s goals often sound more like science fiction than science, but the agency contributed to or created a number of now ubiquitous technologies, including a predecessor to GPS and most famously ARPANET, the computer network that grew into the modern internet.

Unlike more conservative, incremental research teams, DARPA aggressively pursues major scientific advances in a way that shares more in common with Silicon Valley than it does with other governmental agencies. Biden believes that using the DARPA model on cutting edge health research would keep the U.S. from lagging behind in biotech.

“China and other countries are closing in fast,” Biden said during the address. “We have to develop and dominate the products and technologies of the future: advanced batteries, biotechnology, computer chips, and clean energy.”

#arpanet, #biden, #biotechnology, #cancer, #congress, #darpa, #diabetes, #government, #health, #joe-biden, #life-sciences, #national-institute-of-health, #national-institutes-of-health, #president, #tc, #united-states, #white-house

Biden Administration Ends Limit on Fetal Tissue Research

The decision reverses Trump administration rules and allows scientists to use tissue derived from elective abortions to develop treatments for diseases including cancer and AIDS.

#abortion, #coronavirus-2019-ncov, #fetal-tissue, #health-and-human-services-department, #international-society-for-stem-cell-research, #national-institutes-of-health, #research, #science-and-technology, #tissue-human, #trump-donald-j, #vaccination-and-immunization, #your-feed-science

Biden Administration Ends Limits on Use of Fetal Tissue for Research

The decision reverses Trump administration rules and allows scientists to use tissue derived from elective abortions to develop treatments for diseases including cancer and AIDS.

#abortion, #coronavirus-2019-ncov, #fetal-tissue, #health-and-human-services-department, #international-society-for-stem-cell-research, #national-institutes-of-health, #research, #science-and-technology, #tissue-human, #trump-donald-j, #vaccination-and-immunization, #your-feed-science

Joe Biden Made a Promise to Scientists. He Can Still Keep It.

Researchers who receive federal help consistently fail to report their results to the public. The government should hold them accountable.

#clinical-trials, #drugs-pharmaceuticals, #national-institutes-of-health, #research

Drug Prices Are High Thanks to Research That Americans Pay For

The pharmaceutical industry doesn’t want things to change, but Americans can have both lower prices and innovation.

#coronavirus-2019-ncov, #defense-advanced-research-projects-agency, #drugs-pharmaceuticals, #national-institutes-of-health, #prices-fares-fees-and-rates, #research, #vaccination-and-immunization

Rich Countries Signed Away a Chance to Vaccinate the World

Despite warnings, American and European officials gave up leverage that could have guaranteed access for billions of people. That risks prolonging the pandemic.

#astrazeneca-plc, #biontech-se, #coronavirus-2019-ncov, #gamaleya-research-institute-of-epidemiology-and-microbiology, #graham-barney-s-1953, #intellectual-property, #inventions-and-patents, #moderna-inc, #national-institutes-of-health, #politics-and-government, #slaoui-moncef-m, #vaccination-and-immunization

Long Covid is a Looming Health Crisis

Lingering symptoms from the coronavirus may turn out to be one of the largest mass disabling events in modern history.

#chronic-condition-health, #chronic-fatigue-syndrome, #coronavirus-2019-ncov, #coronavirus-risks-and-safety-concerns, #disabilities, #disability-insurance, #national-institutes-of-health, #research, #vaccination-and-immunization

Future Vaccines Depend on Test Subjects in Short Supply: Monkeys

The pandemic has highlighted the United States’ dependence on China for research animals, reviving calls for a “strategic monkey reserve.”

#animal-abuse-rights-and-welfare, #china, #coronavirus-2019-ncov, #international-trade-and-world-market, #monkeys-and-apes, #national-institutes-of-health, #research, #vaccination-and-immunization

With More Vaccines Secured, Biden Warns of Hurdles to Come

The Biden administration has secured more coronavirus vaccines, but the president struck a cautious tone about logistical issues that could keep some Americans from being vaccinated.

#biden-joseph-r-jr, #centers-for-disease-control-and-prevention, #coronavirus-2019-ncov, #national-institutes-of-health, #trump-donald-j, #united-states-politics-and-government, #vaccination-and-immunization

Emil Freireich, Groundbreaking Cancer Researcher, Dies at 93

He helped devise a successful chemotherapy regimen for childhood leukemia, which had long been a death sentence.

#blood-donation, #cancer, #deaths-obituaries, #frei-emil-iii-1924-2013, #freireich-emil, #leukemia, #national-cancer-institute, #national-institutes-of-health, #university-of-texas-m-d-anderson-cancer-center

Governments Sign Secret Vaccine Deals: Here’s What They Hide

Multibillion-dollar contracts give drug makers liability shields, patent ownership and leeway on delivery dates and pricing — and promises that much of it will not be made public.

#astrazeneca-plc, #coalition-for-epidemic-preparedness-innovations, #coronavirus-2019-ncov, #government-contracts-and-procurement, #moderna-inc, #national-institutes-of-health, #novavax-inc, #pfizer-inc, #vaccination-and-immunization, #world-health-organization

Biden Advisers Say U.S. Will Remain Vulnerable to Covid Unless Congress Acts

In pleas for more money from Capitol Hill, the advisers said the United States was still facing shortages of protective gear and other supplies.

#biden-joseph-r-jr, #centers-for-disease-control-and-prevention, #coronavirus-2019-ncov, #fauci-anthony-s, #national-institutes-of-health, #united-states-politics-and-government, #vaccination-and-immunization, #walensky-rochelle, #war-and-emergency-powers-us, #zients-jeffrey-d

Millions Meant for Public Health Threats Were Diverted Elsewhere, Watchdog Says

The money went to unrelated government activities like the removal of office furniture, news subscriptions and legal expenses.

#biden-joseph-r-jr, #bright-rick-a, #coronavirus-2019-ncov, #kadlec-robert-p, #national-institutes-of-health, #united-states-politics-and-government

Warning of Shortages, Researchers Look to Stretch Vaccine Supply

The N.I.H. and Moderna are examining whether doses of Moderna’s coronavirus vaccine can be halved to double the supply, while scientists look for other ways to extend availability.

#clinical-trials, #coronavirus-2019-ncov, #fauci-anthony-s, #moderna-inc, #national-institutes-of-health, #pfizer-inc, #research, #shortages

‘Covid, Covid, Covid’: In Trump’s Final Chapter, a Failure to Rise to the Moment

As the U.S. confronted a new wave of infection and death through the summer and fall, the president’s approach to the pandemic came down to a single question: What would it mean for him?

#atlas-scott-w, #birx-deborah-l, #centers-for-disease-control-and-prevention, #coronavirus-2019-ncov, #fauci-anthony-s, #food-and-drug-administration, #hahn-stephen-m-1960, #health-and-human-services-department, #kushner-jared, #masks, #meadows-mark-r-1959, #national-institutes-of-health, #pence-mike, #presidential-election-of-2020, #trump-donald-j, #united-states-politics-and-government, #vaccination-and-immunization

Trial of High-Dose Blood Thinners in I.C.U. Coronavirus Patients Is Halted

Giving anticoagulants to hospitalized Covid-19 patients is routine. But high doses may sometimes do more harm than good, a safety board finds.

#blood-clots, #clinical-trials, #coronavirus-2019-ncov, #journal-of-the-american-college-of-cardiology, #national-institutes-of-health, #new-york-university, #university-of-pittsburgh-medical-center, #your-feed-healthcare

The Covid-19 Vaccine Doesn’t Mean Big Pharma Is Your Savior

Heroic work went into the development of the coronavirus vaccines. But that doesn’t mean this industry deserves your affection.

#astrazeneca-plc, #biotechnology-and-bioengineering, #centers-for-disease-control-and-prevention, #clinical-trials, #coronavirus-2019-ncov, #drugs-pharmaceuticals, #moderna-inc, #national-institutes-of-health, #oxford-university, #pfizer-inc, #public-private-sector-cooperation, #vaccination-and-immunization

Moderna Vaccine Is Highly Protective and Prevents Severe Covid, Data Show

The positive review likely ensures that the F.D.A. will grant emergency authorization for a second coronavirus vaccine this week for millions of Americans.

#astrazeneca-plc, #clinical-trials, #coronavirus-2019-ncov, #drugs-pharmaceuticals, #food-and-drug-administration, #moderna-inc, #national-institutes-of-health, #united-states-politics-and-government, #your-feed-healthcare

How the US, UK and Canada Will Roll Out the Covid Vaccine

Within days, all three countries could be giving the Pfizer-BioNTech vaccine, but they have varying strategies and challenges. The U.S. plan, working through the states, is the least centralized.

#astrazeneca-plc, #coronavirus-2019-ncov, #european-union, #great-britain, #moderna-inc, #national-health-service, #national-institutes-of-health, #oxford-university, #pfizer-inc, #united-states, #vaccination-and-immunization

The First Covid Vaccine Will Not Make Life Normal Again

Come spring, Americans may have their choice of several so-so coronavirus vaccines — with no way of knowing which one is best.

#clinical-trials, #coronavirus-2019-ncov, #coronavirus-risks-and-safety-concerns, #food-and-drug-administration, #national-institutes-of-health, #placebos, #public-private-sector-cooperation, #research, #united-states-politics-and-government, #vaccination-and-immunization, #your-feed-healthcare, #your-feed-science

Whistle-Blowing Scientist Quits Government With Final Broadside

Dr. Rick Bright, who said he was demoted at the health department for blowing the whistle on a politicized coronavirus response, remains concerned about White House interference.

#biomedical-advanced-research-and-development-authority, #bright-rick-a, #coronavirus-2019-ncov, #health-and-human-services-department, #masks, #national-institutes-of-health, #tests-medical, #united-states-politics-and-government

U.S. Lab Chimps Stuck in Retirement Limbo

Activists and some congressional lawmakers are demanding that the N.I.H. reconsider its refusal to move 39 chimpanzees from a research center to a sanctuary.

#alamogordo-primate-facility, #animal-abuse-rights-and-welfare, #animal-behavior, #chimp-haven, #collins-francis-s, #monkeys-and-apes, #national-institutes-of-health, #research, #your-feed-science

N.I.H. Official Departs After Anonymous Posts Attacking Public Health Leaders

A managing editor of the right-wing website RedState appeared to attack Dr. Anthony S. Fauci and spread misinformation about the coronavirus pandemic while working for Dr. Fauci’s agency.

#conspiracy-theories, #coronavirus-2019-ncov, #crews-william-b, #fauci-anthony-s, #health-and-human-services-department, #masks, #medicine-and-health, #national-institutes-of-health, #redstate-blog, #rumors-and-misinformation, #trump-donald-j, #united-states-politics-and-government

Eli Lilly Claims Experimental Drug Protects Covid-19 Patients

A so-called monoclonal antibody lowered levels of the coronavirus and prevented hospitalizations. The research has not yet been vetted by independent experts.

#antibodies, #clinical-trials, #coronavirus-2019-ncov, #drugs-pharmaceuticals, #eli-lilly-and-company, #national-institutes-of-health, #united-states

Trump Pressed for a Plasma Treatment. Officials Worry, Is a Vaccine Next?

New details of how the president has demanded faster action from health agencies help explain the intensifying concern that he could demand pre-Election Day approval of a vaccine.

#azar-alex-m-ii, #birx-deborah-l, #blood, #clinical-trials, #collins-francis-s, #coronavirus-2019-ncov, #drugs-pharmaceuticals, #food-and-drug-administration, #hahn-stephen-m-1960, #health-and-human-services-department, #kushner-jared, #marks-peter, #mayo-clinic, #meadows-mark-r-1959, #national-institutes-of-health, #presidential-election-of-2020, #republican-national-convention, #trump-donald-j, #united-states-politics-and-government, #vaccination-and-immunization

Backed by Federal Funds, New Virus Tests Are Hitting the Market

Six months into the pandemic and with no coherent national testing strategy, the Trump administration is encouraging private development of an array of faster and cheaper techniques.

#abbott-laboratories, #budgets-and-budgeting, #centers-for-disease-control-and-prevention, #coronavirus-2019-ncov, #fluidigm, #food-and-drug-administration, #giroir-brett-p, #health-and-human-services-department, #national-institutes-of-health, #quidel-corporation, #regulation-and-deregulation-of-industry, #tests-medical, #trump-donald-j, #united-states-politics-and-government