Climate Change and Climate Disaster Must Take Center Stage

Climate changes is a global problem that we must address in our own lives.

#compost, #electric-and-hybrid-vehicles, #global-warming, #internal-sub-only, #north-carolina, #recycling-of-waste-materials

North Carolina Court Strikes Down Voter ID Law

The court cited “persuasive evidence” that the state legislature had rushed the law to passage at least in part to make it harder for Black voters to cast ballots.

#appeals-courts-us, #north-carolina, #republican-party, #voting-rights-registration-and-requirements

The Hunt Is on to Fix the Power Grid

Empowering consumers to control their electric consumption would free up power to meet demand elsewhere.

#air-conditioning, #biden-joseph-r-jr, #california, #electric-light-and-power, #global-warming, #greenhouse-gas-emissions, #home-appliances, #hurricanes-and-tropical-storms, #new-orleans-la, #north-carolina, #oregon, #pacific-northwestern-states-us, #portland-ore, #portland-general-electric-company, #power-failures-and-blackouts

Climate Change Is Bankrupting America’s Small Towns

Repeated shocks from hurricanes, fires and floods are pushing some rural communities, already struggling economically, to the brink of financial collapse.

#area-planning-and-renewal, #army-corps-of-engineers, #buildings-structures, #disasters-and-emergencies, #fair-bluff-nc, #federal-emergency-management-agency, #floods, #global-warming, #greenhouse-gas-emissions, #housing-and-urban-development-department, #hurricanes-and-tropical-storms, #north-carolina, #real-estate-and-housing-residential, #small-business, #southern-states-us, #urban-areas

North Carolina Flooding Leaves 4 Dead and 4 Missing

The remnants of Tropical Storm Fred dropped more than 10 inches of rain on Tuesday in Haywood County, N.C., causing the Pigeon River to overflow.

#cooper-roy-a, #cruso-nc, #deaths-fatalities, #floods, #haywood-county-nc, #hurricanes-and-tropical-storms, #missing-persons, #north-carolina, #pigeon-river-nc-tenn, #rivers

Universal Masking Can Protect Students From Covid

Returning to school this fall, children should be vaccinated if eligible, wear masks or prepare to risk getting Covid. 

#coronavirus-2019-ncov, #education-k-12, #masks, #north-carolina, #shutdowns-institutional, #vaccination-and-immunization

Google faces a major multi-state antitrust lawsuit over Google Play fees

A group of 37 attorneys general filed a second major multi-state antitrust lawsuit against Google Wednesday, accusing the company of abusing its market power to stifle competitors and forcing consumers into in-app payments that grant the company a hefty cut.

New York Attorney General Letitia James is co-leading the suit alongside with the Tennessee, North Carolina and Utah attorneys general. The bipartisan coalition represents 36 U.S. states, including California, Florida, Massachusetts, New Jersey, New Hampshire, Colorado and Washington, as well as the District of Columbia.

“Through its illegal conduct, the company has ensured that hundreds of millions of Android users turn to Google, and only Google, for the millions of applications they may choose to download to their phones and tablets,” James said in a press release. “Worse yet, Google is squeezing the lifeblood out of millions of small businesses that are only seeking to compete.”

In December, 35 states filed a separate antitrust suit against Google, alleging that the company engaged in illegal behavior to maintain a monopoly on the search business. The Justice Department filed its own antitrust case focused on search last October.

In the new lawsuit, embedded below, the bipartisan coalition of states allege that Google uses “misleading” security warnings to keep consumers and developers within its walled app garden, the Google Play store. But the fees that Google collects from Android app developers are likely the meat of the case.

“Not only has Google acted unlawfully to block potential rivals from competing with its Google Play Store, it has profited by improperly locking app developers and consumers into its own payment processing system and then charging high fees,” District of Columbia Attorney General Karl Racine said.

Like Apple, Google herds all app payment processing into its own service, Google Play Billing, and reaps the rewards: a 30 percent cut of all payments. Much of the criticism here is a case that could — and likely will — be made against Apple, which exerts even more control over its own app ecosystem. Google doesn’t have an iMessage equivalent exclusive app that keeps users locked in in quite the same way.

While the lawsuit discusses Google’s “monopoly power” in the app marketplace, the elephant in the room is Apple — Google’s thriving direct competitor in the mobile software space. The lawsuit argues that consumers face pressure to stay locked into the Android ecosystem, but on the Android side at least, much of that is ultimately familiarity and sunk costs. The argument on the Apple side of the equation here is likely much stronger.

The din over tech giants squeezing app developers with high mobile payment fees is just getting louder. The new multi-state lawsuit is the latest beat, but the topic has been white hot since Epic took Apple to court over its desire to bypass Apple’s fees by accepting mobile payments outside the App Store. When Epic set up a workaround, Apple kicked it out of the App Store and Epic Games v. Apple was born.

The Justice Department is reportedly already interested in Apple’s own app store practices, along with many state AGs who could launch a separate suit against the company at any time.

#android, #app-store, #apple, #apple-inc, #attorney-general, #california, #colorado, #companies, #computing, #department-of-justice, #epic-games, #florida, #fortnite, #google, #google-play, #google-play-billing, #google-play-store, #letitia-james, #massachusetts, #new-hampshire, #new-jersey, #new-york, #north-carolina, #search, #social, #tc, #technology, #tennessee, #the-battle-over-big-tech, #united-states, #utah, #washington

Juul to pay N.C. $40M and stop targeting kids after igniting vaping “epidemic“

An attractive young person smokes an e-cigarette.

Enlarge / Juul went with a fashionable, “cool” marketing strategy. (credit: Mass.gov)

Electronic cigarette maker Juul and the state of North Carolina have reached a settlement over the state’s claims that Juul aggressively targeted its “highly addictive” products to youth, igniting a vaping epidemic.

While still denying any wrongdoing, Juul has agreed to pay North Carolina a total of $40 million over the course of six years. Additionally, the company will adhere to a list of restrictions aimed at blocking any promotion and sales of its products to youths. According to the list, Juul won’t use advertisements that may appeal to youth; it will avoid most social media advertising and the use of influencers; it won’t sponsor sports and entertainment events, like concerts; and it won’t use anyone under the age of 35 in its marketing.

The company also agreed to help enforce age restrictions by running a “secret shopper” program. Juul will send undercover representatives, ages 21 to 27, into at least 50 stores throughout the Tar-Heel State per month to check whether retailers are verifying buyers’ ages.

Read 6 remaining paragraphs | Comments

#addiction, #e-cigarettes, #juul, #north-carolina, #science, #tobacco, #vaping

As the Pace of Vaccinations Slows, Biden Makes a Personal Appeal

The Biden administration is shifting its strategy from mass vaccination sites to a more localized effort, deploying top officials to canvass and knock on doors.

#biden-jill-tracy-jacobs, #biden-joseph-r-jr, #coronavirus-2019-ncov, #emhoff-douglas-c, #fauci-anthony-s, #north-carolina, #united-states-politics-and-government, #vaccination-and-immunization

Why Police Have Been Quitting in Droves in the Last Year

Asheville, N.C., has been among the hardest hit by police departures in the wake of last year’s George Floyd protests. About a third of the force quit or retired.

#asheville-nc, #demonstrations-protests-and-riots, #george-floyd-protests-2020, #north-carolina, #police, #police-reform

Child Marriage in North Carolina Must End

Pregnancy and parenting do not justify making a child a bride. 

#children-and-childhood, #marriages, #north-carolina, #sex, #sex-crimes

Tropical Storm Bill Forms Off the East Coast

The weather system, the second named storm of the Atlantic hurricane season, was expected to be short-lived.

#atlantic-ocean, #hurricanes-and-tropical-storms, #national-hurricane-center, #national-oceanic-and-atmospheric-administration, #north-carolina, #tropical-storm-bill, #weather

Summer’s Greatest Prize: Watermelons, With Seeds, Please

For many Americans, juicy, scarlet watermelon is a must for Juneteenth. The heirloom varieties are a sacred summer fruit.

#agriculture-and-farming, #local-food, #north-carolina, #summer-season, #sustainable-living, #watermelons

Coach K’s Retirement From Duke and the End of the College ‘Supercoach’

Mike Krzyzewski of Duke announced his retirement shortly after his Tobacco Road nemesis, Roy Williams, announced his, as the N.C.A.A prepares to grant athletes greater agency.

#basketball-college, #coaches-and-managers, #colleges-and-universities, #duke-university, #krzyzewski-mike, #national-collegiate-athletic-assn, #north-carolina, #university-of-north-carolina, #williams-roy

Student Is Denied High School Diploma for Wearing Mexican Flag

Ever Lopez said he wanted to represent his Mexican roots as he graduated from high school in Asheboro, N.C. The school said the flag violated the ceremony’s dress code.

#asheboro-n-c, #dress-codes, #education-k-12, #flags-emblems-and-insignia, #mexican-americans, #north-carolina, #tiktok-bytedance

At Once Diminished and Dominating, Trump Prepares for His Next Act

The former president speaks on Saturday to the North Carolina Republican convention, as he resumes political speeches and rallies.

#biden-joseph-r-jr, #content-type-personal-profile, #north-carolina, #presidential-election-of-2020, #republican-party, #rumors-and-misinformation, #storming-of-the-us-capitol-jan-2021, #trump-donald-j, #united-states-politics-and-government, #voter-fraud-election-fraud

Andrew Brown Jr. Shooting: Prosecutor Says It Was ‘Justified’

Mr. Brown was fatally shot in Elizabeth City, N.C., by police in April. His family and their lawyers have described it as an “execution.”

#black-lives-matter-movement, #george-floyd-protests-2020, #internal-storyline-no, #north-carolina, #police-brutality-misconduct-and-shootings

Cleared of Murder, Brothers Are Awarded $75 Million

Henry McCollum and Leon Brown, half brothers with intellectual disabilities, spent three decades in prison for the rape and murder of an 11-year-old girl before DNA evidence implicated someone else.

#artis-roscoe, #brown-leon, #capital-punishment, #compensation-for-damages-law, #confessions, #dna-deoxyribonucleic-acid, #false-arrests-convictions-and-imprisonments, #forensic-science, #intellectual-disabilities, #mccollum-henry-lee, #murders-attempted-murders-and-homicides, #north-carolina, #north-carolina-innocence-inquiry-commission, #robeson-county-nc, #sex-crimes, #suits-and-litigation-civil

Police Received Worried Calls Days Before North Carolina Killings

In the days before a 13-hour standoff with the police, the authorities repeatedly heard of a man’s deteriorating mental health. The standoff ended with four people and the gunman dead.

#attacks-on-police, #barnes-isaac-1988-2021, #boone-nc, #fox-logan-watauga-county-nc-police-officer, #mental-health-and-disorders, #murders-attempted-murders-and-homicides, #north-carolina, #paranoia, #ward-chris-watauga-county-nc-police-officer

How 4 New Jersey pools turned into a startup that just raised $10M

As the oldest of 12 children, Bunim Laskin spent much of his teen years looking for ways to help keep his siblings entertained. Noticing that a neighbor’s pool was often empty, Laskin reached out to ask if his family could use her pool. To make it worth her while, he suggested that they could help cover her expenses for maintaining the pool.

Soon after, five other families had made the same arrangement with her and the pool owner had six families covering 25% of her expenses. This meant that the neighbor was actually making money off her pool. The arrangement sparked a business idea in Laskin’s mind. At the age of 20, he founded Swimply, a marketplace for homeowners to rent out their underutilized pools to local swimmers, with Asher Weinberger.

The Cedarhurst, New York-based company launched a beta in 2018, starting with four pools in the New Jersey area. 

“We used Google Earth to find houses, and then knocked on 80 doors with a pool,” Laskin recalls. “We got to 100 pools organically. Word of mouth really helped us grow.” The site was pretty bare bones, he admits, with potential customers only able to view photos of the pools and connect with the pool owner by phone.

That year, Swimply did around 400 reservations and raised $1.2 million from friends and family.

In 2019, Swimply launched what he describes as a “proper” website and app with an automated platform. It grew “4 to 5 times” that year, again mostly organically. In an episode that aired in March 2020, the company appeared on Shark Tank but went home without a deal.

Then the COVID-19 pandemic hit. Swimply, Laskin said, pivoted right into the pandemic.

“We were the perfect solution for people when the world was falling on its head,” he said. The company restructured its offering to ensure that pool owners did not have to interact with guests. “It was the perfect, contact-free, self-serve experience to hang out and be with people you quarantined with.”

The CDC then came out to say that it was safe to swim because chlorine could help kill the virus, and that proved to be a big boon to its business.

“On one end, it was a way for people to have a normal day and on the other, it helped give owners a way to earn an income, at a time when many people were being affected financially,” Laskin told TechCrunch.

Business took off in 2020 with revenue growing 4,000% and now Swimply is announcing a $10 million Series A round. Norwest Venture Partners led the financing, which also included participation from Trust Ventures and a number of angel investors such as Poshmark founder and CEO Manish Chandra; Rob Chesnut, former general counsel and chief ethics officer at Airbnb; Ancestry.com CEO Deborah Liu and Michael Curtis. 

Swimply is now operating in a total of 125 U.S. markets, two markets in Canada and five markets in Australia. It plans to use its new capital in part to expand into new markets and toward product development.

Image Credits: Swimply

The way it works is pretty straightforward. Swimply simply connects homeowners that have underutilized backyard spaces and pools with those seeking a way to gather, cool off or exercise, for example. People or families can rent pools by the hour, ranging in price from $15 to $60 per hour (at an average of $45/hour) depending on the amenities. New markets that Swimply has recently expanded to include Portland, Oregon; Raleigh, NC and the California cities of Oakland, San Luis Obispo and Los Gatos. 

“The shifting mindset from younger generations about ownership is a huge contributor to increased growth of the Swimply marketplace,” said co-founder Weinberger, who serves as Swimply’s COO. “Swimming is the third most popular activity for adults and number one for children, and yet no other company has tackled the aquatic space to make swimming more affordable and accessible…until now.”

While the company declined to provide hard revenue figures, Laskin said Swimply was seeing “7 digits a month in revenue” and 15,000 to 20,000 reservations a month. Families represent the most popular reservation.

“People can book and pay through our platform, and only 20% of hosts ever meet their guests,” Laskin said. “We’re enabling a new kind of consumer behavior with what we’re doing.”

The company is planning to use its new capital to also rebuild much of its tech infrastructure and boost its customer support team to be more “readily available.”

It is also now offering a complimentary up to $1 million worth of insurance per booking for liability as well as $10,000.

Swimply has a little over 20 employees, up 10 times from 2 people in December of 2020. It plans to double that number over the next few months.

The company’s model has proven quite lucrative for some owners, according to Laskin.

“Last year, there were some owners who earned $10,000 a month. One owner in Denver earned $50,000 last year and he had signed up toward the end of the summer. He should make over $100,000 this year,” Lasken projects.

Its only criteria is that owners offer a clean pool. Eighty five percent of hosts offer restrooms as well. If they don’t, they are limited to one-hour reservations with a max of five guests. Swimply has also partnered with local pool companies, and if they pay one of its owners a visit and certify that pool, that owner gets a badge on the site “so guests get an additional level of security,” Laskin said.

Ed Yip of Norwest Venture Partners admits that when he first heard of the concept of Swimply, he “didn’t know what to make of it.”

But the more he heard about it, the more excited he got.

“This is the holy grail for a consumer investor. We’re not changing consumer behavior, but rather productize the experience and make it safer and easier on both sides,” Yip told TechCrunch.

What also gets the investor excited is the potential for Swimply beyond just swimming pools in the future.

“We’re seeing a ton of demand from hosts wanting to list hot tubs and tennis courts, for example,” Yip said. “So this can turn into a marketplace for shared outdoor resources and that’s a huge market opportunity that adds value on both sides.”

Indeed, the concept of monetizing underutilized space is a growing concept. Earlier this year, we reported on Neighbor, which operates a self-storage marketplace, raising $53 million in a Series B round of funding. Neighbor’s unique model aims to repurpose under-utilized or vacant space — whether it be a person’s basement or the empty floor of an office building — and turn it into storage.

 

 

#airbnb, #ancestry-com, #australia, #california, #canada, #ceo, #co-founder, #coo, #denver, #entertainment, #funding, #fundings-exits, #manish-chandra, #new-jersey, #north-carolina, #norwest-venture-partners, #oakland, #oregon, #pool, #portland, #poshmark, #raleigh, #recent-funding, #renting, #sports, #startup, #startups, #tc, #united-states, #venture-capital

4 People, Including 2 Deputies, Killed in North Carolina Standoff

A 13-hour standoff with a gunman, who barricaded himself inside a house in Boone, N.C., ended at about 11 p.m. on Wednesday. Officials said the gunman had also died.

#attacks-on-police, #boone-nc, #chris-ward, #logan-fox, #murders-attempted-murders-and-homicides, #north-carolina

Apple commits to 20,000 US jobs, new North Carolina campus

Apple this morning announced a sweeping plan to invest north of $430 billion over the next five years. The company says the deal involves “economic benefits” in all 50 states and would create, all told, 20,000 additional jobs in the United States over that time period.

The plan is an extension of one it announced in 2018, raising the original $350 billion goal by 20%. At the center of the announcement is the long anticipated creation of an additional campus in North Carolina. That involves a $1 billion investment in the Research Triangle, including 3,000 jobs that will focus on emerging fields like machine learning and AI.

“Innovation has long been North Carolina’s calling card and Apple’s decision to build this new campus in the Research Triangle showcases the importance of our state’s favorable business climate, world-class universities, our tech-ready workforce, and the welcoming and diverse communities that make so many people want to call North Carolina home,” state leaders said in a joint statement. “This announcement will benefit communities across our state and we are proud to work together to continue to grow our economy and bring transformational industries and good paying jobs to North Carolina.”

The company has also outlined a $100 million fund for community and schools in the surrounding Raleigh-Durham area, as well as a $110 million spend on infrastructure.

“At this moment of recovery and rebuilding, Apple is doubling down on our commitment to US innovation and manufacturing with a generational investment reaching communities across all 50 states,” Tim Cook said in a release tied to the news. “We’re creating jobs in cutting-edge fields — from 5G to silicon engineering to artificial intelligence — investing in the next generation of innovative new businesses, and in all our work, building toward a greener and more equitable future.”

Other US operation initiatives have been outlined for the company’s native California, as well as Colorado, Texas, Washington and Iowa. California gets the biggest initial boost here, with 5,000 more employees being added to its San Diego office and 3,000 more for Culver City. Indiana, Kentucky and Texas has already begun adding positions as part of the $5 billion Advanced Manufacturing Fund the company launched in 2017.

The news comes a week after Wisconsin announced plans to dramatically scale back the creation of a Foxconn plant set to manufacture flatscreen TVs. During his presidency, Donald Trump had called the planned factory, “the eighth wonder of the world,” and central to his plans to return manufacturing to the U.S. while courting various high profile tech executives, including Cook.

#apple, #labor, #manufacturing, #north-carolina

Sheriff’s Deputy Kills Black Man in North Carolina

The Pasquotank County Sheriff’s Office said that a deputy who was executing a search warrant fatally shot Andrew Brown Jr. in Elizabeth City, N.C. Residents gathered at the scene to demand answers.

#andrew-brown-jr, #black-people, #elizabeth-city, #elizabeth-city-n-c, #george-floyd-protests-2020, #murders-attempted-murders-and-homicides, #north-carolina, #police, #police-brutality-misconduct-and-shootings

There’s a Booming Business in America’s Forests. Some Aren’t Happy About It.

The fuel pellet industry is thriving. Supporters see it as a climate-friendly source of rural jobs. For others, it’s a polluter and destroyer of nature.

#bioenergy-and-biofuels, #forests-and-forestry, #global-warming, #greenhouse-gas-emissions, #north-carolina, #wood-and-wood-products

A Bobcat Attacks, and a Husband Swings Into Action

Kristi Wade credits her husband, Happy Wade, with saving her life when a rabid bobcat attacked her in their North Carolina driveway.

#animal-behavior, #animals, #burgaw-n-c, #cats, #north-carolina, #rabies

From Serial: The Improvement Association

A true story about election fraud.

#bladen-county-nc, #corruption-institutional, #elections-house-of-representatives, #new-york-times, #north-carolina, #presidential-election-of-2020, #serial-productions, #united-states-politics-and-government, #voter-fraud-election-fraud

Planting seed investments on tech’s frontiers nets KdT Ventures $50 million for its latest fund

Like other venture investors over the past year, Cain McClary, co-founder of the investment firm KdT Ventures, recently made the jump to Austin. But unlike the rest of them, he was coming from Black Mountain, NC.

McClary had spent the better part of the last three years with his co-founder Mack Healy building out a portfolio that would be the envy of almost any investor looking at financing startups whose businesses depend on innovations at the borders of current technological achievement.

Since 2017, when the firm closed on the first $3.5 million of what ended up being a $15 million fund (they had targeted $30 million), McClary and Healy managed to find their way onto the cap table of businesses like the green chemicals manufacturer, Solugen; health diagnostics technology developer, PathAI; the Nigerian genetic dataset developer, 54Gene; the novel biomaterials developer, Checkerspot; and the genetics-focused therapy company, Dyno Therapeutics. 

That portfolio — and the subsequent top decile performance that Cambridge Associates has said comes with it — has allowed McClary and Healy to close on an oversubscribed $50 million new fund to invest in promising startup companies.

KdT co-founders Cain McClary and Mack Healy. Image Credit: KdT Ventures

Hailing from a small Tennessee town outside of Leipers Fork (itself a small Tennessee town) McClary studied medicine at Tulane and business at Stanford where he linked up with Healy through a mutual friend.

Healy, who had done stints throughout big Bay Area startups like Airbnb, Databricks, and Facebook brought the software expertise (and some capital to stake the firm) while McClary provided the life sciences know-how.

Together the two men set out to hang their investment shingle at the intersection of software and life sciences that was proving to be fertile ground for new business creation. Each company in the firm’s portfolio depends on both the advances in understanding how to code computers and living cells.

McClary had left California for personal reasons when he launched the fund in 2017 and in 2020 relocated to Austin for professional ones. Healy had already set up shop in the city and it was easier, McClary said to fly out to San Francisco to look for companies from the Austin airport than it was from Ashville.

Also, both men were placing big bets on the Dell Medical School at the University of Texas to become the breeding ground for the type of entrepreneurs that the firm is looking to back.

Mack was there… the Dell Medical School and we think it’s going to be produce the types of entrpereneurs that we want to support. Houston has a med system. I firmly believe that texas has a place at the table in the future 

“The way that we define it is that we like to invest in the physical layer of the world,” said McClary. “That includes not only medicine, but chemicals and agriculture. All of that is driven by some of the things that we have this sourcecode for the physical world.”

Mapping the unmapped corners of the frontier tech startup world means that the firm not only has a presence in Austin, but has hired principals to scour Houston and Research Triangle Park in North Carolina for hot deals.

That doesn’t mean the firm is forsaking California though. One of the most recent deals in the KdT portfolio is Andes Ag, an Emeryville, Calif.-based startup that’s applying yield-boosting microbes directly to seeds in an effort to improve crop performance for farmers.

“The KdT team speaks the language of science, making them an outlier in this area of venture investing,” said JD Montgomery of Canterbury Consulting, a limited partner in KdT’s first and second fund. “They are passionate about building the science companies of the future that will tackle some of the significant challenges our world faces in the next decade and beyond.”

#54gene, #airbnb, #austin, #california, #cambridge-associates, #chemicals, #co-founder, #corporate-finance, #databricks, #dell, #economy, #entrepreneurship, #facebook, #finance, #fork, #houston, #money, #north-carolina, #partner, #pathai, #private-equity, #san-francisco, #solugen, #stanford, #startup-company, #tc, #texas, #tulane, #university-of-texas, #venture-capital

‘Dear G.I.’: An Unlikely Friendship Built on Letters From a Foxhole

In 1966, a Massachusetts mother of three began writing to young men serving in Vietnam. One became her most steadfast pen pal, writing her 77 letters over seven years.

#black-people, #letters, #massachusetts, #north-carolina, #politics-and-government, #veterans, #vietnam-war

Tiny Town, Big Decision: What Are We Willing to Pay to Fight the Rising Sea?

On the Outer Banks, homeowners in Avon are confronting a tax increase of almost 50 percent to protect their homes, the only road into town, and perhaps the community’s very existence.

#coast-erosion, #coastal-areas, #global-warming, #greenhouse-gas-emissions, #north-carolina, #oceans-and-seas, #outer-banks-nc, #property-taxes

Woman’s Search for Her Birth Parents Leads to a Story of Murder

Kathy Gillcrist said a DNA test she took in 2017 revealed that her father may have been William Bradford Bishop Jr., a fugitive suspected of killing his wife, mother and three sons in 1976.

#adoptions, #bethesda-md, #bishop-william-bradford-jr, #content-type-personal-profile, #dna-deoxyribonucleic-acid, #fugitives, #genealogy, #gillcrist-kathy-1957, #murders-attempted-murders-and-homicides, #north-carolina, #tests-medical

New clinical trial data from Locus Biosciences shows promise in CRISPR-Cas3 technology

Antibiotic resistance is one of the biggest potential threats to global health today. But Locus Biosciences is hoping that their crPhage technology might provide a new solution.

Based in North Carolina’s Research Triangle, the startup recently announced promising phase 1b clinical trial results for their use of CRISPR-Cas3-enhanced bacteriophages as a treatment for urinary tract infections caused by escherichia coli. Led in part by former Patheon executive and current Locus CEO Paul Garofolo, the startup launched in 2015 with the goal of using a less popular application of CRISPR technology to address growing antimicrobial resistance.

CRISPR-Cas3 technology has notably different mechanisms from its more well-known CRISPR-Cas9 counterpart. Where the Cas9 enzyme has the ability to cleanly cut through a piece of DNA like a pair of scissors, Garofolo describes Cas3 more like a Pac-Man, shredding the DNA as it moves along a strand.

“You wouldn’t be able to use it for most of the editing platforms people were after,” he said, noting that meant there wouldn’t be as much competition around Cas3. “So I knew it would be protected for some time, and that we could keep it quiet.”

Garofolo and his team wanted to use CRISPR-Cas3 not to edit harmful bacteria found in the body, but to destroy it. To do this, they took the DNA-shredding mechanism of Cas3 and used it to enhance bacteriophages—viruses that can attack and kill different species of bacteria. Together, co-founder and Chief Scientific Officer Dave Ousterout—who has a Ph.D. in biomedical engineering from Duke—thinks this technology offers an extremely direct and targeted way of killing bacteria.

“We armed the phages with this Cas3 system that attacks E. coli, and that sort of dual mechanism of action is what comes together, essentially, as a really potent way to remove just E. coli,” he said in an interview.

That specificity is something that antibiotics lack. Rather than targeting only harmful bacteria in the body, antibiotics typically wipe out all bacteria they come across. “Every time we take antibiotics, we’re not thinking about all the other parts of us that are impacted by the bacteria that do good things,” said Garofolo. But the precision of Locus Biosciences’ crPhage technology means that only the targeted bacteria would be wiped out, leaving those necessary to the body’s normal function intact.

Beyond offering this more specific approach to treatment of pathogens, or any bacteria-based disease, Garofolo and his team also suspect that their approach will also be extremely safe. Though deadly to bacteria, bacteriophages are typically harmless to humans. The safety of CRISPR in humans is well-established, too.

“That’s our secret sauce,” said Garofolo. “We can build drugs that are more powerful than the antibiotics they’re trying to replace, and they use phage, which is probably one of the world’s safest ways to deliver something into the human body.”

While this new technology could certainly help treat pathogens and infectious diseases, Garofolo hopes that indications in immunology, oncology, and neurology might benefit from it too. “We’re starting to figure out that some bacteria might promote cancer, or inflammation in your gut,” he said. If researchers can identify the bacteria at the root cause of those conditions, Garofolo and Ousterout think the crPhage technology might prove to be an effective treatment.

“If we’re right about that, it’s not just about infections or antimicrobial resistance, but helping people overcome cancer or delay the onset of dementia,” Garofolo said. “It’s changing the way we think about how bacteria really help us live.”


Early Stage is the premier ‘how-to’ event for startup entrepreneurs and investors. You’ll hear first-hand how some of the most successful founders and VCs build their businesses, raise money and manage their portfolios. We’ll cover every aspect of company-building: Fundraising, recruiting, sales, product market fit, PR, marketing and brand building. Each session also has audience participation built-in – there’s ample time included for audience questions and discussion.

#biology, #biotech, #biotechnology, #cancer, #cas-3, #crispr, #enzymes, #genetic-engineering, #health, #life-sciences, #locus-biosciences, #north-carolina, #science, #startups

North Carolina Officer Slams Dog Into Car, Prompting Investigation

A video obtained by a TV station appears to show an officer in Salisbury, N.C., hoisting a police dog off the ground by its leash and shoving it into the side of an S.U.V.

#dogs, #north-carolina, #police, #police-brutality-misconduct-and-shootings, #police-department-salisbury-nc, #salisbury-nc

Margaret Maron, Acclaimed Mystery Writer, Dies at 82

She was known for two book series centered on complex female characters, and for stories that illuminated her native North Carolina.

#books-and-literature, #deaths-obituaries, #maron-margaret, #north-carolina, #take-out-book, #women-and-girls, #writing-and-writers

North Carolina Republicans Censure Richard Burr Over Impeachment Vote

The senator, who is retiring, is one of seven Republicans who voted with Democrats to find Donald J. Trump guilty of inciting an insurrection at the Capitol.

#burr-richard-m, #elections-senate, #impeachment, #north-carolina, #republican-party, #trump-donald-j, #trump-lara-1982, #united-states-politics-and-government

Lara Trump for North Carolina Senate Seat? Trump’s Trial Is Renewing Talk

Senator Richard M. Burr’s vote to convict the former president has intensified speculation that Ms. Trump might galvanize staunch Trump loyalists behind a possible bid for Mr. Burr’s seat in 2022.

#burr-richard-m, #elections-senate, #impeachment, #north-carolina, #republican-party, #senate, #storming-of-the-us-capitol-jan-2021, #trump-lara-1982, #united-states-politics-and-government

Man Is Charged With Threatening to Kill Biden

David K. Reeves of North Carolina made the threats over a period of several days ending on Feb. 2, in calls to the White House, the U.S. Capitol Police and a Secret Service agent, prosecutors said.

#biden-joseph-r-jr, #north-carolina, #reeves-david-k, #secret-service, #threats-and-threatening-messages, #united-states, #united-states-politics-and-government

America’s First Moonshine, Applejack, Returns in Sleeker Style

From the Blue Ridge Mountains to Vermont, new distillers are reviving a drink that vanished during Prohibition, giving it the age and polish of a fine brandy.

#alcoholic-beverages, #appalachian-region, #apples, #catoctin-creek-distilling-co-llc, #cider, #holman-distillery-moravian-falls-nc, #neversink-spirits-port-chester-ny-distillery, #new-york-state, #north-carolina, #prohibition-era-1920-1933, #small-business, #vermont

Folx Health raises $25 million for virtual clinical offerings and care for the LGBTQIA+ community

Folx Health is leveraging the explosion of virtual care services to offer greater access to healthcare focused on the needs of the LGBTQIA+ community, and has raised $25 million in new funding to help it grow.

It’s part of a revolution in care that’s targeting the needs of specific communities with access to physicians that understand those needs. And it’s all made possible by virtual interactions.

“We have a good sense of the nature of the need and the depth of the pain in the community,” said A.G. Breitenstein, the founder and chief executive of Folx Health. “As a non-binary lesbian and healthcare industry veteran, I have seen and experienced firsthand just how broken the current system is for the queer and trans community,”

Breitenstein said Folx would be using the cash to try and expand to all fifty states and increase the available products and services the healthcare company would look to make available to the queer and trans community.

“Whether it’s HRT, PrEP, sexual health or family creation, health care is essential for us to be who we are. It’s about time we build a platform for ourselves, so Queer and Trans people feel seen, heard, and celebrated,” she said in a statement. 

That was one reason why Bessemer Venture Partners leapt at the chance to lead the new financing round for Folx, according to Morgan Cheatham, an investor out of Bessemer’s New York office. The other was the size of the market.

“At a high level, 2% of the population identify as transgender,” said Cheatham. “At that math, when we looked at that, we were able to see a multibillion dollar market opportunity not just to provide [hormone replacement therapy], but to provide a healthcare destination for this community.”

Telescoping out to the opportunity to provide care to the LGBTQ community broadly, when that population represents about 10% to 20% of the population is a “deca-billion opportunity,” said Cheatham.

Breitenstein envisions offering family planning services, broad primary care, and sexual health and wellness care in addition to the hormone therapies that the company currently offers.

Folx joins a cohort of companies tackling health issues specifically for the LGBTQIA+ community which include the mental healthcare service, Violet; Included Health, an employee benefit service; and Plume, which focuses on care for the transgender community.

“We believed in the vision and the approach that she’s taking. She’s building a healthcare experience that is celebratory and dignified rather than one that pathologizing healthcare,” said Cheatham. 

For Bessemer and Cheatham, the investment speaks to broader opportunities to identify specific populations that need care tailored to their specific experience. That includes companies like Spora Health and Live Chair Health, which focus on providing healthcare specifically to people of color.

“Our individual identities whether it be socioeconomic status, race, gender… All of these things inform how we interface with the medical industrial complex,” Cheatham said.

Previous investors Define Ventures and Polaris Venture Partners will also participate in the round, which follows quickly on the heels of Folx’s launch from stealth in December 2020. 

For its patients, Folx Health is offering Hormone Replacement Therapy (HRT: testosterone or estrogen) with monthly plans starting at $59 a month. Folx Health will also begin releasing its sexual health and wellness offerings starting with Erectile Dysfunction (ED) treatment, soon to be followed by at-home STI Testing and Treatment, all customized for the specifics of Queer and Trans bodies, the company said. 

The services will include unlimited on-demand clinical support with at-home lab testing (for most plans) and home-delivered medications (costs may vary based on medication). The company’s services are now available in California, Connecticut, Delaware, Florida, Illinois, Massachusetts, North Carolina, New York, Texas, Virginia, and Washington.

The company is also launching a Folx Library, which will serve as a content hub and resource for Queer and Trans health, written by Folx clinicians and its broader community.

“Our partnership with Folx is a historical moment. It’s challenging to articulate how transformative Folx is for our community. We do so mindful of the brilliant and brave Queer and Trans people who fought for this moment to happen,” said Cheatham in a statement.

#california, #connecticut, #define-ventures, #delaware, #erectile-dysfunction, #florida, #healthcare, #healthcare-industry, #illinois, #massachusetts, #new-york, #north-carolina, #polaris-venture-partners, #spora-health, #tc, #texas, #virginia, #washington

North Carolina Discontinues License Plates With Confederate Flag

The Division of Motor Vehicles said it had received complaints about the specialty plate, which had been issued to members of the Sons of Confederate Veterans.

#automobile-registration-and-license-plates, #automobiles, #confederate-states-of-america, #flags-emblems-and-insignia, #north-carolina, #slavery-historical, #sons-of-confederate-veterans, #southern-states-us

Sarah Huckabee Sanders Is Running for Office. Will Other Trump Allies Follow?

The names of Lara Trump, Ivanka Trump, Donald Trump Jr. and others have been floated as potential political candidates. Here’s what we know about the chances they could run and their considerations.

#elections-senate, #florida, #mcenany-kayleigh, #meadows-mark-r-1959, #north-carolina, #presidential-election-of-2024, #primaries-and-caucuses, #republican-party, #sanders-sarah-huckabee, #trump-donald-j, #trump-donald-j-jr, #trump-ivanka, #trump-lara-1982, #united-states-politics-and-government

Justice Dept. Ends Stock Trade Inquiry Into Richard Burr Without Charges

Law enforcement officials told the senator that they would not pursue charges over his dumping of hundreds of thousands of dollars of stock after Senate coronavirus briefings early in the pandemic.

#burr-richard-m, #conflicts-of-interest, #coronavirus-2019-ncov, #insider-trading, #justice-department, #north-carolina, #senate, #senate-committee-on-intelligence, #united-states-politics-and-government

Home services platform Porch acquires four companies

Only a few weeks after its SPAC IPO, Porch today announced that it has made four acquisitions, worth a total of $122 million. The most important here is probably the acquisition of Homeowners of America for $100 million, which gets Porch deeper into the home insurance space. In addition, Porch is also acquiring mover marketing and data platform V12 for $22 million, as well as home inspection service Palm-Tech and iRoofing, a SaaS application for roofing contractors. Porch did not disclose the acquisition prices for the latter two companies.

You may still think of Porch as a marketplace for home improvement and repair services — and that’s what it started out as when it launched about seven years ago. Yet while it still offers those services, a couple of years after its 2013 launch, the company pivoted to building what it now calls a “vertical software platform for the home.” Through a number of acquisitions, the Porch Group now includes Porch.com, as well as services like HireAHelper, Inspection Support Network for home inspectors, Kandela for providing services around moving and an insurance broker in the form of the Elite Insurance Group. In some form or another, Porch’s tools are now used — either directly or indirectly — by two-thirds of U.S. homebuyers every month.

Porch founder and CEO Matt Ehrlichman. Image Credits: Porch

As Porch founder and CEO Matt Ehrlichman told me, he had originally planned to take his company public through a traditional IPO. He noted that going the increasingly popular SPAC route, though, allowed him to push his timeline up by a year, which in turn now enables the company to make the acquisitions it announced today.

“In total, we had a $323 million fundraise that allows us now to not only be a public company with public currency, but to be very well capitalized. And picking up that year allows us to be able to go and pursue acquisitions that we think make really good fits for Porch,” Ehrlichman told me. While Porch’s guidance for its 2021 revenue was previously $120 million, it’s now updating that guidance to $170 million based on these acquisitions. That would mean Porch would grow its revenue by about 134% year-over-year between 2020 and 2021.

As the company had previously laid out in its public documents, the plan for 2021 was always to get deeper into insurance. Indeed, as Ehrlichman noted, Porch these days tends to think of itself as a vertical software company that layers insurtech on top of its services in order to be able to create a recurring revenue stream. And because Porch offers such a wide range of services already, its customer acquisition costs are essentially zero for these services.

Image Credits: Homeowners of America

Porch was already a licensed insurance brokerage. With Homeowners of America, it is acquiring a company that is both an insurance carrier as well as a managing general agent..

“We’re able to capture all of the economic value from the consumer as we help them get insurance set up with their new home and we can really control that experience to delight them. As we wrap all the technology we’ve invested in around that experience we can make it super simple and instant to be able to get the right insurance at the right price for your new home. And because we have all of this data about the home that nobody else has — from the inspection we know if the roof is old, we know if the hot water system is gonna break soon and all the appliances — we know all of this data and so it just gives us a really big advantage in insurance.”

Data, indeed, is what a lot of these acquisitions are about. Because Porch knows so much about so many customers, it is able to provide the companies it acquires with access to relevant data, which in turn helps them offer additional services and make smarter decisions.

Homeowners of America is currently operating in six states (Texas, Arizona, North Carolina, South Carolina, Virginia and Georgia) and licensed in 31. It has a network of more than 800 agencies so far and Porch expects to expand the company’s network and geographic reach in the coming months. “Because we have [customer acquisition cost]-free demand all across the country, one of the opportunities for us is simply just to expand that across the nation,” Ehrlichman explained.

As for V12, Porch’s focus is on that company’s mover marketing and data platform. The acquisition should help it reach its medium-term goal of building a $200 million revenue stream in this area. V12 offers services across multiple verticals, though, including in the automotive space, and will continue to do so. The platform’s overall focus is to help brands identify the right time to reach out to a given consumer — maybe before they decide to buy a new car or move. With Porch’s existing data layered on top of V12’s existing capabilities, the company expects that it will be able to expand these features and it will also allow Porch to not offer mover marketing but what Ehrlichman called “pro-mover” services, as well.

“V12 anchors what we call our marketing software division. A key focus of that is mover marketing. That’s where it’s going to have, long term, tremendous differentiation. But there are a number of other things that they’re working on that are going to have really nice growth vectors, and they’ll continue to push those,” said Ehrlichman.

As for the two smaller acquisitions of iRoofing and Palm-Tech, these are more akin to some of the previous acquisitions the company made in the contractor and inspection verticals. Like with those previous acquisitions, the plan is to help them grow faster, in part through integrating them into the overall Porch group’s family of products.

“Our business is and continues to be highly recurring or reoccurring in nature,” said Porch CFO Marty Heimbigner. “Nearly all of our revenues, including that of these new acquisitions, is consistent and predictable. This repeat revenue is also high margin with less than 20% cost of revenue and is expected to grow more than 30% per year on our platform. So, we believe these deals are highly accretive for our shareholders.”

#arizona, #contractor, #exit, #finance, #financial-services, #georgia, #ing-group, #insurance, #insurance-broker, #ma, #mergers-and-acquisitions, #north-carolina, #porch, #real-estate, #software, #software-platform, #south-carolina, #tc, #texas, #united-states, #virginia

Duke Women’s Basketball Season is Cancelled After Four Games

The team is the first Power Five basketball team to start and stop its season because of the pandemic. The men’s basketball team is expected to continue playing.

#basketball-college, #college-athletics, #coronavirus-2019-ncov, #duke-university, #national-collegiate-athletic-assn, #north-carolina

Peloton to acquire fitness equipment maker Precor in $420M bid to grow commercial business

Peloton has announced that it intends to acquire Precor, one of the world’s largest suppliers of commercial fitness equipment. You probably recognize the Precor brand name if you’ve ever spent time in a hotel or standalone commercial gym, which is exactly why Peloton making this purchase makes a ton of sense at this particular time for the hot home workout brand.

The Precor acquisition will be made via a deal that’s valued at a total of $420 million, and in addition to expanding its commercial business, this also helps Peloton bring on a lot more manufacturing capability in a time when its order queue for its Tread and Bike hardware is deeper than ever, thanks to the increase in demand resulting from the COVID-19 pandemic. Precor already maintains a significant U.S.-based manufacturing operation, as well as dedicated research and development teams and facilities. In total, Peloton says in a press release that it’ll be adding 625,000 square feet of manufacturing facility in the U.S., between Precor facilities in both Whitsett, North Carolina, and Woodinville, Washington.

While the near-term use of the acquisition, which is set to close in 2021 if it meets all approvals, is to speed up delivery times for customers of existing equipment, long-term this deal sets Peloton up nicely for greater commercial market expansion – once the commercial market returns to growth. While the pandemic has been a clear boon for Peloton’s at-home equipment and fitness subscription service, it’s also been devastating for gym chains and hoteliers, meaning that it’s likely Precor’s primary business was taking a considerable hit over the past few months.

This is the largest deal that Peloton has made thus far, but it’s possible it picked up Precor for a relative bargain; Precor owner Anta Sports was said to have been seeking a potential sale fo the company for around $500 million last November. Peloton will be installing Precor President Rob Barker as GM of Peloton Commercial as part of the new deal, and that should help it accelerate the infiltration of its connected equipment in commercial gyms globally once people feel more comfortable about returning to them safely post-pandemic.

#companies, #fitness, #hardware, #health, #ma, #north-carolina, #peloton, #precore, #president, #tc, #united-states, #washington

Escape From the City: 9 Winter Outings That Fight Cabin Fever

Snow biking near Seattle, winter bird-watching near New York and seven other cold-weather activities near large U.S. cities.

#arizona, #boston-mass, #chesapeake-bay, #chicago-ill, #coronavirus-2019-ncov, #cross-country-skiing, #hikes-and-hiking, #los-angeles-calif, #north-carolina, #parks-and-other-recreation-areas, #seattle-wash, #sedona-ariz, #skiing, #snowshoes, #tampa-fla, #travel-and-vacations, #winter-season

Drug-Dealing Network Alleged at Duke, U.N.C. Chapel Hill and Appalachian State

Prosecutors said current or former students were part of an operation that funneled thousands of pounds of marijuana, hundreds of kilograms of cocaine and other drugs to fraternities and colleges campuses.

#appalachian-state-university, #beta-theta-pi, #chapel-hill-nc, #colleges-and-universities, #drug-abuse-and-traffic, #duke-university, #fraternities-and-sororities, #north-carolina, #ochoa-francisco-javier-jr, #poindexter-charles, #university-of-north-carolina

Biden to Pick Michael Regan, North Carolina Environment Regulator, to Head E.P.A.

Mr. Regan, a former air quality specialist at the Environmental Protection Agency, is secretary of North Carolina’s Department of Environmental Quality.

#appointments-and-executive-changes, #biden-joseph-r-jr, #environment, #environmental-protection-agency, #global-warming, #greenhouse-gas-emissions, #north-carolina, #regan-michael-s, #united-states-politics-and-government

Black Student Expelled After Mother Complains About ‘Fences’

A dispute about the reading of August Wilson’s Pulitzer Prize-winning play in an English class escalated at the mostly white Providence Day School in Charlotte, N.C.

#black-people, #books-and-literature, #charlotte-nc, #discrimination, #education-k-12, #floyd-george-d-2020, #george-floyd-protests-2020, #instagram-inc, #north-carolina, #parenting, #pulitzer-prizes, #race-and-ethnicity, #washington-denzel, #wilson-august

Storm May Bring Over 6 Inches of Snow From Virginia to New England

Some areas north and west of the Interstate 95 corridor in New Jersey and Pennsylvania may get more than a foot of snow on Wednesday, the National Weather Service said.

#cuomo-andrew-m, #delaware, #east-coast-us, #interstate-95, #national-weather-service, #new-jersey, #new-york-city, #new-york-metropolitan-area, #new-york-state, #north-carolina, #northeastern-states-us, #pennsylvania, #philadelphia-pa, #restaurants, #snow-and-snowstorms, #virginia, #weather

Could State Legislatures Pick Their Own Electors to Vote for Trump? Not Likely

Some Trump allies have suggested that Republican lawmakers should override the will of voters who elected Joe Biden the next president.

#arizona, #electoral-college, #georgia, #michigan, #north-carolina, #pennsylvania, #presidential-election-of-2020, #republican-party, #state-legislatures, #trump-donald-j